维生素D辅助治疗在儿童过敏性哮喘患儿中的效果及对肠道菌群、免疫功能的影响  

Effects of Vitamin D Adjuvant Therapy on Intestinal Flora and Immune Function in Children with Allergic Asthma

作　　者：马歆花 杨艳娥[1] 李兆坤 耿宝宝 齐雪[1] MA Xin-hua;YANG Yan-e;LI Zhao-kun;GENG Bao-bao;QI Xue(Department of Pediatrics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,710038,China)

机构地区：[1]西安医学院第二附属医院儿科,陕西西安710038

出　　处：《现代生物医学进展》2024年第22期4288-4290,4323,共4页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(S2020-YF-YBSF-0597)。

摘　　要：目的:探讨维生素D辅助治疗在儿童过敏性哮喘患儿中的效果及对肠道菌群、免疫功能的影响。方法:选择2021年1月至2023年12月来我院诊治的儿童过敏性哮喘患儿120例,分为对照组与联合组,对照组患儿行常规治疗,联合组在对照组基础上口服维生素D3,两组均治疗6个月。对比两组患儿相关指标。结果:治疗后,两组患儿症状、用药积分降低,免疫功能指标改善,肠道菌群改善、联合组优于对照组(P<0.05),联合组不良反应发生率较对照组无差异(P>0.05)。结论:维生素D辅助治疗可明显改善儿童过敏性哮喘的临床疗效,可能与其改善患儿的免疫功能、肠道菌群有关。Objective:To explore the effect of vitamin D adjuvant therapy in children with allergic asthma and its effects on intestinal flora and immune function.Methods:120 children with allergic asthma in our hospital from January 2021 to December 2023 were divided into control group and combination group with oral vitamin D3 in the control group,and both groups were treated for 6 months.Compare the two groups of children.Results:After treatment,the symptoms and medication points of the two groups were reduced,the immune function index was improved,the intestinal flora was improved,and the combination group was better than the control group(P<0.05),and the incidence of adverse reactions in the combination groupwas no different than that in the control group(P>0.05).Conclusion:The adjuvant therapy with vitamin D can significantly improve the clinical effects of allergic asthma in children,which may be related to the improvement of the immune function and intestinal flora of the children.

关 键 词：维生素D 儿童过敏性哮喘 免疫功能 肠道菌群 

分 类 号：R562.25[医药卫生—呼吸系统] R725.6[医药卫生—内科学]