子宫内膜-肌层交界区超声参数联合血清TGF-β1、COX-2对子宫腺肌病的诊断价值分析  

Diagnostic Value of Ultrasound Parameters of Endometrium-myometrium Junction Combined with Serum TGF-β1 and COX-2 in Adenomyosis

作　　者：侯小霞 周浔丹 胡春艳 楚光华 王伟强 HOU Xiao-xia;ZHOU Xun-dan;HU Chun-yan;CHU Guang-hua;WANG Wei-qiang(Medical Ultrasound Center,Northwest Women and Children's Hospital,Xi'an,Shaanxi,710061,China;Gynecology Department,Northwest Women and Children's Hospital,Xi'an,Shaanxi,710061,China)

机构地区：[1]西北妇女儿童医院医学超声中心,陕西西安710061 [2]西北妇女儿童医院妇科,陕西西安710061

出　　处：《现代生物医学进展》2024年第22期4320-4323,共4页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2021SF-208)。

摘　　要：目的:探讨EMI超声参数联合血清TGF-β1、COX-2对子宫腺肌病的诊断价值。方法:回顾性选择2021.1-2023.1月子宫腺肌病患者110例为观察组,同期健康女性110例为对照组,所有受试者均行相同的检查及手术操作,对比两组受试者的相关指标对子宫腺肌病的诊断价值。结果:观察组年龄明显较对照组高;73.64%子宫腺肌病患者的EMI超声表现异常;观察组EMI超声各项参数比对照组低,P均<0.05。观察组的血清TGF-β1、COX-2水平明显较对照组高,P<0.05。EMI平均厚度增大、形态异常、TGF-β1、COX-2水平升高是子宫腺肌病的危险因素,EMI血流指数升高是子宫腺肌病的保护因素,P均<0.05。其中,EMI平均厚度、形态、TGF-β1、COX-2水平、血流指数及以上指标联合对子宫腺肌病均有较好的诊断价值,P均<0.05,但指标联合对子宫腺肌病的AUC面积较其他指标大,可用于子宫腺肌病诊断。结论:EMI超声参数联合血清TGF-β1、COX-2可用于子宫腺肌病的诊断。Objective:To investigate the diagnostic value of EMI ultrasound parameters combined with serum TGF-β1 and COX-2 for adenomyosis.Methods:Retrospective selection of 110 patients with adenomyosis from January 2021 to March 2023 as the observation group and 110 healthy women as the control group during the same period.All subjects underwent the same examinations and surgical procedures.Compare the diagnostic value of relevant indicators between two groups of subjects for adenomyosis.Results:The age of the observation group was significantly higher than that of the control group;73.64%of patients with adenomyosis have abnormal EMI ultrasound findings;The EMI ultrasound parameters in the observation group were lower than those in the control group,with P values<0.05.The serum levels of TGF-β1 and COX-2 in the observation group were higher than those in the control group,with P<0.05.Increased average thickness,abnormal morphology,and elevated levels of TGF-β1 and COX-2 in EMI were risk factors for adenomyosis,while elevated EMI blood flow index was a protective factor for adenomyosis,with P<0.05 for both.Among them,the average thickness and morphology of EMI;The combination of TGF-β1,COX-2 levels,blood flow index,and above indicators has good diagnostic value for adenomyosis,with P values<0.05.However,the AUC area of the combination of indicators for adenomyosis is larger than other indicators and can be used for the diagnosis of adenomyosis.Conclusion:EMI ultrasound parameters combined with serum TGF-β1 and COX-2 can be used for the diagnosis of adenomyosis.

关 键 词：EMI超声参数 TGF-β1 COX-2 

分 类 号：R711.74[医药卫生—妇产科学]