抑制素B、骨形态发生蛋白15在早发性卵巢功能不全血清中表达意义及与治疗后妊娠失败的关系分析  

The Expression Significance of Statin B and Bone Morphogenetic Protein 15 in Serum of Premature Ovarian Insufficiency and Their Relationship with Pregnancy Loss after Treatment

作　　者：王婧[1] 阿依努尔·买苏提 阿孜古丽·阿力木江 李丹 陆萍[1] WANG Jing;Ayinuer·Maisuti;Aziguli·Alimujiang;LI Dan;LU Ping(Gynecological Medicine Diagnosis and Treatment Center,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830000,China;Department of Reproductive Medicine,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang,830000,China)

机构地区：[1]新疆维吾尔自治区人民医院妇科医学诊疗中心,新疆乌鲁木齐830000 [2]新疆维吾尔自治区人民医院生殖医学科,新疆乌鲁木齐830000

出　　处：《现代生物医学进展》2024年第22期4358-4360,共3页Progress in Modern Biomedicine

基　　金：新疆维吾尔自治区自然科学基金项目(2021D01C209)。

摘　　要：目的:分析抑制素B、骨形态发生蛋白15在早发性卵巢功能不全血清中表达意义及与治疗后妊娠失败的关系。方法:选择我院自2021.6-2023.6收治的102例早发性卵巢功能不全患者纳入观察组,分为绝经组和非绝经组。另选同期的102例体检健康且月经正常的妇女纳入对照组,分析相关指标。结果:观察组血清抑制素B、骨形态发生蛋白15表达水平均更低(P<0.05);绝经组血清抑制素B、骨形态发生蛋白15表达水平均低于非绝经组(P<0.05);早发性卵巢功能不全患者血清抑制素B、骨形态发生蛋白15表达水平均与促黄体生成素、卵泡刺激素呈负相关,与雌二醇呈正相关(P<0.05);低抑制素B组治疗后妊娠失败率高于高抑制素B组,低骨形态发生蛋白15组治疗后妊娠失败率高于高骨形态发生蛋白15组(P<0.05);血清抑制素B联合骨形态发生蛋白15的敏感度为92.52%、特异度为63.47%、AUC为0.915。结论:早发性卵巢功能不全患者血清抑制素B和骨形态发生蛋白15表达均下调,与卵巢功能减退程度密切相关,联合预测治疗后妊娠失败的效能较好。Objective:To analyze the significance of the expression of inhibin B and bone morphogenetic protein 15 in serum of premature ovarian insufficiency and their relationship with pregnancy failure after treatment.Methods:102 patients with early-onset ovarian insufficiency admitted from 2021.6-2023.6 were selected for the observation group and were divided into menopausal and non-menopausal groups.In addition,102 women with healthy physical examination and normal menstruation in the same period were included in the control group to analyze relevant indicators.Results:The expression levels of serum inhibin B and bone morphogenic protein 15 were all lower in the observation group(P<0.05);The expression levels of serum inhibin B and bone morphogenic protein 15 in the menopausal group were all lower than those in the non-menopausal group(P<0.05);The expression levels of serum inhibin B and bone morphogenic protein 15 in patients with early-onset ovarian insufficiency were both negatively correlated with luteinizing hormone and FSH,A positive correlation with oestradiol(P<0.05);A higher pregnancy failure rate after treatment in the low inhibin B group than in the high inhibin B group,The posttreatment pregnancy failure rate was higher in low bone morphogen protein group 15 than in high bone morphogen protein group 15(P<0.05);Serum inhibin B combined with bone morphogenetic protein 15 showed a sensitivity of 92.52%,a specificity of 63.47%,and an AUC of 0.915.Conclusion:Serum inhibin B and bone morphogenic protein 15 were both downregulated in patients with early-onset ovarian insufficiency,which is closely related to the degree of ovarian dysfunction,and was better combined to predict pregnancy failure after treatment.

关 键 词：早发性卵巢功能不全 抑制素B 骨形态发生蛋白15 卵巢功能 妊娠失败 

分 类 号：R711.75[医药卫生—妇产科学]