自然周期IVF/M结合卵母细胞胞浆内单精子注射在男性不育症中的临床应用  

Clinical Application of Natural Cycle IVF/M Combined with Oocyte Intracytoplasmic Sperm Injection in Male Infertility

作　　者：赵梦思 肖育红 徐晓杭 张凌雪 于月新 ZHAO Meng-si;XIAO Yu-hong;XU Xiao-hang;ZHANG Ling-xue;YU Yue-xin(Department of Reproductive Medicine,Northern Theater General Hospital,Shenyang,Liaoning,110000,China)

机构地区：[1]北部战区总医院生殖医学科,辽宁沈阳110000

出　　处：《现代生物医学进展》2024年第22期4373-4375,共3页Progress in Modern Biomedicine

基　　金：军队计生项目(21JSZ11)。

摘　　要：目的:探讨自然周期IVF/M结合卵母细胞ICSI在男性不育症中的临床应用。方法:2018.1-2023.8行辅助生殖助孕治疗的男性不孕症患者200例,按照男性少精子、弱精子、无精子原因分为3组。患者行PESA或TESA,接受72个自然周期IVF/M。比较3组卵母细胞胚胎发育情况、妊娠和分娩情况。结果:3组促排卵方案、Gn使用时间、Gn总用量、雌二醇、黄体生成素、移植日子宫内膜厚度、卵母细胞数、未成熟卵母细胞数、成熟卵母细胞数、受精卵母细胞数、卵裂率、可移植胚胎率、优质胚胎率比较无差异(P>0.05)。无精子组临床妊娠率高于弱精子组、少精子组(P<0.05)。结论:自然周期IVF/M结合ICSI对于治疗少弱精子症及无精子症等男性不育症是一种简便有效的方法。Objective:To explore the clinical application of natural cycle IV F/M combined with oocyte ICSI in male infertility.Methods:2018.1-2023.8200 male infertility patients treated with assisted reproduction were divided into three groups according to the causes of less sperm,weak sperm and no sperm.Patients underwent either PESA or TESA and received 72 natural cycles of IV F/M.Comparing oocyte embryo development,pregnancy and delivery in the 3 groups.Results:There was no difference in the three groups of ovulation induction regimen,Gn use time,total Gn dosage,estradiol,LH,endometrial thickness,oocytes,immature oocytes,mature oocytes,cleavage rate,transplantable rate,and rate of high-quality embryos(P>0.05).The clinical pregnancy rate in anspermatozoa group was higher than that in weak sperm group and oligosperm group(P<0.05).Conclusion:Natural cycle IVF/M combined with ICSI is a simple and effective method to treat male infertility such as oligoasthenospermia and azoospermia.

关 键 词：男性不育症 体外受精 未成熟卵母细胞 精子注射 

分 类 号：R6982[医药卫生—泌尿科学]