生长激素缺乏症患儿行重组人生长激素治疗前后维生素D水平的变化及其预后影响因素分析  

Growth Hormone Deficiency Role of Recombinant Human Growth Hormone Treatment before and after the Change of the Vitamin D Levels and Its Prognostic Factors Analysis

作　　者：齐雪[1] 任婷婷 常侨 王彦华[1] 李兆坤 QI Xue;REN Ting-ting;CHANG Qiao;WANG Yan-hua;LI Zhao-kun(Department of Pediatrics,The Second Affiliated Hospital of Xi'an Medical University,Xi'an,Shaanxi,710038,China)

机构地区：[1]西安医学院第二附属医院儿科,陕西西安710038

出　　处：《现代生物医学进展》2024年第22期4376-4378,4400,共4页Progress in Modern Biomedicine

基　　金：国科金青年培育项目(24KY0104)。

摘　　要：目的:分析生长激素缺乏症患儿行重组人生长激素治疗前后维生素D水平的变化及其预后影响因素。方法:选择2020.2-2023.2期间收治的80例生长激素缺乏症患儿,予以重组人生长激素治疗。比较相关指标并分析预后影响因素。结果:生长激素缺乏症患儿治疗后身高、身高标准差积分、生长速率均较治疗前增大(P<0.05);生长激素缺乏症患儿治疗后血清IGF-1、IGFBP-3表达水平均较治疗前升高(P<0.05);生长激素缺乏症患儿治疗后血清25(OH)D3、1,25-(OH)2D3表达水平均较治疗前升高(P<0.05);经单因素和多因素Logistic回归分析,治疗前生长速率、治疗前骨龄成熟度、母体孕期合并症均是生长激素缺乏症患儿行重组人生长激素治疗后预后的独立影响因素(P<0.05)。结论:生长激素缺乏症患儿行重组人生长激素治疗的促生长效果确切,有助于促进维生素D的代谢,但预后受治疗前生长速率、治疗前骨龄成熟度和母体孕期合并症的影响。Objective:To analyze the changes of vitamin D levels and prognostic factors in children with growth hormone deficiency before and after treatment with recombinant human growth hormone.Methods:80 children with GH deficiency admitted during 2020.2-2023.2 were selected for recombinant human GH therapy.Compare relevant indicators and analyze prognostic factors.Results:The height,height standard deviation score and growth rate of children with GH deficiency increased compared with those before treatment(P<0.05);The serum expression levels of IGF-1 and IGFBP-3 in children with GH deficiency increased compared with those before treatment(P<0.05);Serum 25(OH)D3,1,The expression level of 25-(OH)2D3 was increased compared with that before treatment(P<0.05);After the univariate and multivariate Logistic regression analysis,Pre-treatment growth rate,bone age maturity,and maternal pregnancy comorbidities were all independent factors for outcomes in children with GH deficiency(P<0.05).Conclusion:The growth-promoting effect of recombinant human growth hormone treatment helps to promote the metabolism of vitamin D,but the prognosis is influenced by pre-treatment growth rate,pre-treatment bone age maturity and maternal pregnancy comorbidities.

关 键 词：生长激素缺乏症 重组人生长激素 维生素D 

分 类 号：Q57[生物学—生物化学] Q56