胎盘早剥孕妇血浆t-PAIC、TAT水平的变化意义及其与病情严重程度、弥散性血管内凝血的关系  

Plasma t-pregnant Women of Placental Abruption PAIC,TAT Level Changes in the Meaning and the Disease Severity,the Relationship between Diffuse Intravascular Coagulation

作　　者：张雪[1] 赵刚[1] 毛会 王海艳[1] 牛艳华 ZHANG Xue;ZHAO Gang;MAO Hui;WANG Hai-yan;NIU Yan-hua(Department of Obstetrics and Gynecology,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710000,China;Department of Laboratory Medicine,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi,710089,China)

机构地区：[1]西安交通大学第二附属医院妇产科,陕西西安710000 [2]西安交通大学第一附属医院检验科,陕西西安710089

出　　处：《现代生物医学进展》2024年第22期4379-4381,共3页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2022SF-126)。

摘　　要：目的:分析胎盘早剥孕妇血浆t-PAIC、TAT水平的变化意义及其与病情严重程度、弥散性血管内凝血的关系。方法:选择自2018.6-2023.6接受规律产检的105例胎盘早剥孕妇为观察组,根据严重程度分为轻型组和重型组;另选同期的105例正常妊娠孕妇纳入对照组。检测指标并分析相关性、诊断价值。结果:观察组血浆t-PAIC、TAT水平均高于对照组(P<0.05);重型组血浆t-PAIC、TAT水平均高于轻型组(P<0.05);胎盘早剥孕妇血浆t-PAIC、TAT水平均与其分娩出血量呈正相关(P<0.05);血浆t-PAIC联合TAT预测重型胎盘早剥的敏感度为89.43%、特异度为61.23%、AUC为0.901;血浆t-PAIC联合TAT预测胎盘早剥孕妇发生弥散性血管内凝血的敏感度为92.56%、特异度为60.47%、AUC为0.920。结论:胎盘早剥孕妇血浆t-PAIC、TAT水平均升高,与其病情严重程度有关,联合应用可进一步提高对继发弥散性血管内凝血的预测效能。Objective:To analyze the significance of plasma tissue plasminogen activator inhibitor complex(t-PAIC)and thrombinase-antithrombin complex(TAT)levels in pregnant women with placental abruption and their relationship with disease severity and disseminated intravascular coagulation.Methods:105 pregnant women with placental abruption who underwent regular examination from 2018.6-2023.6 were selected for observation and divided into light and heavy groups according to severity;105 normal pregnant women in the same period were included in the control group.Test the indicators and analyze the correlation and diagnostic value.Results:The plasma levels of t-PAIC and TAT in the observation group were higher than that in the control group(P<0.05);Plasma t-PAIC and TAT levels in the heavy group were higher than those in the light group(P<0.05);The plasma t-PAIC and TAT levels in pregnant women with placental abruption were positively correlated with their delivery bleeding volume(P<0.05);Plasma t-PAIC and TAT predicted the sensitivity of heavy placental abruption as 89.43%,61.23%specific,and AUC as 0.901;Plasma t-PAIC combined with TAT predicted the sensitivity of 92.56%,60.47%specificity and 0.920 AUC in pregnant women with placental abruption.Conclusion:The plasma levels of t-PAIC and TAT are increased in pregnant women with placental abruption,which are related to the severity of their disease,and the combination can further improve the predictive efficacy of secondary disseminated intravascular coagulation.

关 键 词：胎盘早剥 t-PAIC TAT 严重程度 弥散性血管内凝血 

分 类 号：R714.462[医药卫生—妇产科学]