血清CXCL12/CXCR4/CXCR7信号轴水平与狼疮性肾炎患者疾病活动度及预后的关系研究  

Study on Relationship between Serum CXCL12/CXCR4/CXCR7 Signal Axis Level and Disease Activity and Prognosis in Patients with Lupus Nephritis

作　　者：冯福龙 薛娟[2] 马利军[2] 白雪冬 包涵 张正祥[1] FENG Fu-long;XUE Juan;MA Li-jun;BAI Xue-dong;BAO Han;ZHANG Zheng-xiang(BasicMedicine School of Yan'an University,Yan'an,Shaanxi,716000,China;Department of Laboratory,Yan'an University Affiliated Hospital,Yan'an,Shaanxi,716000,China;Department of Laboratory,Inner Mongolia Baogang Group Third Employee Hospital,Baotou,Inner Mongolia,014010,China;Department of Rheumatology and Immunology,Ordos Dongsheng District People's Hospital,Ordos,Inner Mongolia,017099,China)

机构地区：[1]延安大学基础医学院,陕西延安716000 [2]延安大学附属医院检验科,陕西延安716000 [3]内蒙古包钢集团第三职工医院检验科,内蒙古包头014010 [4]鄂尔多斯市东胜区人民医院风湿免疫科,内蒙古鄂尔多斯017099

出　　处：《现代生物医学进展》2024年第22期4397-4400,共4页Progress in Modern Biomedicine

基　　金：陕西省重点研发计划项目(2022SF-393)。

摘　　要：目的:探讨血清趋化因子C-X-C基元配体12(CXCL12)、趋化因子C-X-C基元受体4(CXCR4)、趋化因子C-X-C基元受体7(CXCR7)表达水平与狼疮性肾炎(LN)患者疾病活动度及预后的关系。方法:选择LN患者274例为LN组,根据LN患者疾病活动度分为LN活动组(n=146)和LN稳定组(n=128),另选择体检健康的志愿者274例为健康对照组。采用Pearson法分析主要临床指标的相关性。随访2年,根据LN患者预后情况将其分为预后良好组(n=198)和预后不良组(n=70)。采用多因素Logistic回归分析影响因素。结果:LN组血清CXCL12、CXCR4、CXCR7表达水平高于健康对照组(P<0.05)。LN活动组尿蛋白、C反应蛋白(CRP)、CXCL12、CXCR4、CXCR7水平高于LN稳定组,补体C3、补体C4水平低于LN稳定组(P<0.05)。LN患者血清CXCL12、CXCR4、CXCR7表达水平与尿蛋白、CRP呈正相关,与补体C3、补体C4呈负相关(P<0.05)。尿蛋白、CXCL12、CXCR4、CXCR7水平升高是LN患者预后不良的独立危险因素(P<0.05)。结论:LN患者血清CXCL12、CXCR4、CXCR7表达水平升高,与LN患者疾病活动度及预后不良密切相关。Objective:To investigate the relationship between the expression levels of serum chemokine C-X-C motif ligand 12(CXCL12),chemokine C-X-C motif receptor 4(CXCR4),chemokine C-X-C motif receptor 7(CXCR7),disease activity and prognosis in patients with lupus nephritis(LN).Methods:274 patients with LN were selected as LN group.Patients were divided into LN active group(n=146)and LN stable group(n=128)according to the disease activity of LN patients,and 274 healthy volunteers were selected as the healthy control group.The correlation of main clinical indicators were analyzed by Pearson method.2 years after follow-up,patients with LN were categorized into a good prognosis group(n=198)and a poor prognosis group(n=70)based on their prognosis.The influencing factors were analyzed by multivariate Logistic regression analysis.Results:The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN group were higher than those in healthy control group(P<0.05).The levels of urinary protein,C-reactive protein(CRP),CXCL12,CXCR4 and CXCR7 in LN active group were higher than those in LN stable group,and the levels of complement C3 and complement C4 were lower than those in LN stable group(P<0.05).The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN patients were positively correlated with urinary protein and CRP,and negatively correlated with complement C3 and complement C4(P<0.05).Elevated levels of urinary protein,CXCL12,CXCR4 and CXCR7 were independent risk factors for poor prognosis in LN patients(P<0.05).Conclusion:The expression levels of serum CXCL12,CXCR4 and CXCR7 in LN patients are increased,which are closely related to the disease activity and poor prognosis of LN patients.

关 键 词：狼疮性肾炎 CXCL12 CXCR4 CXCR7 疾病活动度 预后 

分 类 号：R593.24[医药卫生—内科学]