血清cTnⅠ、ApoB、ApoA1水平与急性心肌梗死患者冠脉病变程度的相关性分析  

Analysis on Correlations of Serum cTnⅠ,ApoB and ApoA1 Levels with Severity Degree of Coronary Artery Lesions in Patients with Acute Myocardial Infarction

作　　者：谢孟颖 葛卫卫 XIE Mengying;GE Weiwei(Clinical Laboratory,Luohe Third People's Hospital,Luohe 462300,China)

机构地区：[1]漯河市第三人民医院检验科,河南漯河462300

出　　处：《临床医学工程》2024年第12期1495-1496,共2页Clinical Medicine & Engineering

摘　　要：目的探讨血清肌钙蛋白Ⅰ(cTnⅠ)、载脂蛋白B(ApoB)、载脂蛋白A1(ApoA1)水平与急性心肌梗死(AMI)患者冠脉病变程度的相关性。方法选取96例AMI患者纳入研究组,48例健康者纳入参照组,比较两组的血清cTnⅠ、ApoB、ApoA1水平。将研究组患者根据Gensini评分分为轻度病变亚组、中度病变亚组和重度病变亚组,比较各亚组的血清cTnⅠ、ApoB、ApoA1水平,分析血清cTnⅠ、ApoB、ApoA1水平与AMI患者冠脉病变程度的相关性。结果研究组的血清cTnⅠ、ApoB水平均高于参照组,ApoA1水平均低于参照组(P<0.05)。研究组中,重度病变亚组、中度病变亚组、轻度病变亚组的血清cTnⅠ、ApoB水平依次降低,ApoA1水平依次升高(P<0.05)。Spearman相关性分析显示,血清cTnⅠ、ApoB水平与AMI患者的冠脉病变程度呈明显正相关,血清ApoA1水平与AMI患者冠脉病变程度呈明显负相关(P<0.05)。结论血清cTnⅠ、ApoB、ApoA1与AMI患者的冠脉病变程度具有一定相关性,可作为重要辅助指标。Objective To explore the correlations of serum cardiac troponinⅠ(cTnⅠ),apolipoprotein B(ApoB)and apolipoprotein A1(ApoA1)levels with severity degree of coronary artery lesions in patients with acute myocardial infarction(AMI).Methods 96 patients with AMI were selected as the study group,48 healthy subjects were selected as the reference group,and the levels of serum cTnⅠ,ApoB and ApoA1 were compared between the two groups.The patients in the study group were divided into the mild lesion subgroup,the moderate lesion subgroup and the severe lesion subgroup according to Gensini score,the levels of serum cTnⅠ,ApoB and ApoA1 in each subgroup were compared,and the correlations of serum cTnⅠ,ApoB and ApoA1 levels with the severity degree of coronary artery lesions were analyzed.Results The levels of serum cTnⅠand ApoB in the study group were higher than those in the reference group,and the level of ApoA1 was lower than that in the reference group(P<0.05).In the study group,the levels of serum cTnⅠand ApoB in the severe lesion subgroup,the moderate lesion subgroup and the mild lesion subgroup decreased in turn,and the level of ApoA1 increased in turn(P<0.05).Spearman correlation analysis showed that serum cTnI and ApoB levels were significantly positively correlated with the levels of serum cTnⅠand ApoB,and negatively correlated with the level of ApoA1(P<0.05).Conclusions Serum cTnⅠ,ApoB and ApoA1 have certain correlations with severity degree of coronary artery lesions in patients with AMI,which can be used as important auxiliary indicators.

关 键 词：肌钙蛋白Ⅰ 载脂蛋白B 载脂蛋白A1 急性心肌梗死 冠脉病变程度 相关性 

分 类 号：R541[医药卫生—心血管疾病]