吲哚布芬联合替格瑞洛在老年冠心病患者PCI术后的应用效果  

Application Effect of Indobufen Combined with Ticagrelor in Elderly Patients with Coronary Heart Disease After PCI

作　　者：党安建 刘兆捷 李嘉晨 张振岭 DANG Anjian;LIU Zhaojie;LI Jiachen;ZHANG Zhenling(Department of Clinical Pharmacy,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;Department of Endodscope,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China;2^(rd)Department of Cardiology,the First Affiliated Hospital of Xinxiang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院临床药学学部,河南新乡453100 [2]新乡医学院第一附属医院内窥镜检查科,河南新乡453100 [3]新乡医学院第一附属医院心内二科,河南新乡453100

出　　处：《临床医学工程》2024年第12期1505-1506,共2页Clinical Medicine & Engineering

摘　　要：目的探讨吲哚布芬联合替格瑞洛在老年冠心病患者经皮冠状动脉介入(PCI)术后的应用效果。方法72例行PCI术的老年冠心病患者根据术后用药的不同分为两组。PCI术后,参照组采用替格瑞洛+阿司匹林治疗,研究组采用吲哚布芬+替格瑞洛治疗。比较两组的血小板活性、凝血功能、MACE发生率。结果用药3个月后,研究组的MPAR、PRU水平均低于参照组,PT、APTT均短于参照组,TT长于参照组(P<0.05)。研究组的MACE发生率为1.11%,低于参照组的30.56%(P<0.05)。结论吲哚布芬联合替格瑞洛能够明显改善老年冠心病患者PCI术后的血小板活性以及凝血功能,降低患者MACE发生风险。Objective To explore the application effect of indobufen combined with ticagrelor in elderly patients with coronary heart disease after percutaneous coronary intervention(PCI)surgery.Methods 72 elderly patients with coronary heart disease who underwent PCI surgery were divided into two groups according to different postoperative medications.After PCI surgery,the reference group was treated with ticagrelor+aspirin,and the study group was treated with indobufen+ticagrelor.The platelet activity,coagulation function and incidence of MACE were compared between the two groups.Results After 3 months of medication,the levels of MPAR and PRU in the study group were lower than those in the reference group,PT and APTT were shorter than those in the reference group,and TT was longer than that in the reference group(P<0.05).The incidence of MACE in the study group was 1.11%,lower than 30.56%in the reference group(P<0.05).Conclusions Indobufen combined with ticagrelor can obviously improve platelet activity and coagulation function of elderly patients with coronary heart disease after PCI surgery,and reduce the occurrence risk of MACE.

关 键 词：替格瑞洛 吲哚布芬 老年 冠心病 PCI术 血小板活性 凝血功能 

分 类 号：R541.4[医药卫生—心血管疾病]