TCRosetta:An Integrated Analysis and Annotation Platform for T-cell Receptor Sequences  

作　　者：Tao Yue Si-Yi Chen Wen-Kang Shen Zhan-Ye Zhang Liming Cheng An-Yuan Guo 

机构地区：[1]Center for Artificial Intelligence Biology,Hubei Bioinformatics&Molecular Imaging Key Laboratory,College of Life Science and Technology,Huazhong University of Science and Technology,Wuhan 430074,China [2]Department of Laboratory Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China [3]Department of Thoracic Surgery,West China Biomedical Big Data Center,West China Hospital,Sichuan University,Chengdu 610041,China

出　　处：《Genomics, Proteomics & Bioinformatics》2024年第4期181-190,共10页基因组蛋白质组与生物信息学报（英文版）

基　　金：supported by the National Key R&D Program of China(Grant No.2021YFF0703704);the National Natural Science Foundation of China(Grant No.32370717).

摘　　要：T cells and T-cell receptors(TCRs)are essential components of the adaptive immune system.Characterization of the TCR repertoire offers a promising and highly informative source for understanding the functions of T cells in the immune response and immunotherapy.Although TCR repertoire studies have attracted much attention,there are few online servers available for TCR repertoire analysis,especially for TCR sequence annotation or advanced analyses.Therefore,we developed TCRosetta,a comprehensive online server that integrates analytical methods for TCR repertoire analysis and visualization.TCRosetta combines general feature analysis,large-scale sequence clustering,network construction,peptide–TCR binding prediction,generation probability calculation,and k-mer motif analysis for TCR sequences,making TCR data analysis as simple as possible.The TCRosetta server accepts multiple input data formats and can analyze�20,000 TCR sequences in less than 3 min.TCRosetta is the most comprehensive web server available for TCR repertoire analysis and is freely available at https://guolab.wchscu.cn/TCRosetta/.

关 键 词：T-cell receptor TCR repertoire analysis Batch search ANNOTATION Web server. 

分 类 号：R392[医药卫生—免疫学]