植物来源细胞外囊泡在创面修复中作用的研究进展  

Research advances on the role of plant-derived extracellular vesicles in wound repair

作　　者：王玮琪 羊月婷 苏志宏 李瑾 胡文慧 张培华 Wang Weiqi;Yang Yueting;Su Zhihong;Li Jin;Hu Wenhui;Zhang Peihua(Institute of Plastic Surgery,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China;Department of Orthopaedics,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524001,China)

机构地区：[1]广东医科大学附属医院整形外科研究所,湛江524001 [2]广东医科大学附属医院骨科,湛江524001

出　　处：《中华烧伤与创面修复杂志》2024年第12期1199-1204,共6页Chinese Journal of Burns And Wounds

基　　金：国家干细胞临床研究项目(MR-44-21-015762);广东省省级科技计划项目(2016A020214018)。

摘　　要：植物来源细胞外囊泡(EV)为植物细胞分泌的纳米级囊泡,含有各种蛋白质、脂质及RNA分子,能调节细胞之间的信息交流、物质传递,是细胞通信的重要载体。当前,动物来源EV在种间通信、细胞交流和药物载体研究中得到广泛应用;而植物来源EV由于具有优越的生物相容性和靶向性及低免疫原性已受到人们的普遍重视,与此同时植物来源EV研究和分析技术已取得较大进展。该综述围绕植物来源EV分离技术、表征鉴定及其在创面修复中的作用等方面进行阐述,旨在为今后植物来源EV研究提供新思路和新途径,并为其临床应用提供借鉴。Plant-derived extracellular vesicles(EVs)are nanoscale vesicles secreted by plant cells,containing various proteins,lipids,and RNA molecules,which can regulate the information exchange and material transfer between cells,thus are important carriers of cellular communication.Currently,animal-derived EVs have been widely used in interspecies communication,cellular exchange,and drug carrier research;while plant-derived EVs have received widespread attention due to their superior biocompatibility and targeting and low immunogenicity.At the same time,research and analysis techniques of plant-derived EVs have made great progress.This review focuses on the isolation techniques,characterization and identification of plant-derived EVs and their role in wound repair,aiming to provide new ideas and avenues for future research on plant-derived EVs and to provide reference for their clinical applications.

关 键 词：胞外囊泡 植物 组织工程 离心法 细胞增殖 免疫调节 创面修复 

分 类 号：R641[医药卫生—外科学]