Discovery of biosynthetic enzymes forβ-D-manno-heptoses across kingdoms:novel agonists for ALPK1/NF-κB-dependent immune response  

作　　者：Gunter Maubach Michelle C.C.Lim Michael Naumann 

机构地区：[1]Otto von Guericke University,Institute of Experimental Internal Medicine,Medical Faculty,Magdeburg,Germany

出　　处：《Signal Transduction and Targeted Therapy》2024年第11期4760-4762,共3页信号转导与靶向治疗（英文）

基　　金：supported in part by DFG grant NA292/17-1.

摘　　要：A recent study by Tang et al.1 in Science reveals the crosskingdom widespread occurrence of functional nucleotidediphosphate(NDP)-heptose biosynthetic enzymes(HBEs)that accounts for the synthesis of NDP-heptoses to activate the alphaprotein kinase 1(ALPK1)-dependent innate immune response.This study not only highlights the importance of the metaboliteβ-D-manno-heptose as pathogen-associated molecular patterns(PAMPs)but also raises the question of possibly other biological roles,especially in the different kingdoms(Fig.1).

关 键 词：king response. RAISE 

分 类 号：R392[医药卫生—免疫学]