川崎病免疫发病机制研究进展  

Advances in immunopathogenesis of Kawasaki disease

作　　者：那巍兰 宋红梅[2] 黄国英[1,3] Na Weilan;Song Hongmei;Huang Guoying(Children's Hospital of Fudan University,Shanghai Key Laboratory of Birth Defects,Shanghai 201102,China;Department of Pediatrics,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Research Unit of Early Intervention of Genetically Related Childhood Cardiovascular Diseases,Chinese Academy of Medical Sciences,Shanghai 201102,China)

机构地区：[1]复旦大学附属儿科医院、上海市出生缺陷防治重点实验室,201102 [2]中国医学科学院北京协和医学院、北京协和医院儿科,100730 [3]中国医学科学院小儿遗传相关心血管疾病早期防控创新单元,上海201102

出　　处：《国际儿科学杂志》2024年第11期721-724,共4页International Journal of Pediatrics

基　　金：中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-002);上海市申康医院发展中心三年行动计划(SHDC2020CR5011-002)。

摘　　要：川崎病是一种好发于5岁以下儿童的急性系统性血管炎, 病因尚不明确。目前认为川崎病是遗传易感个体的免疫系统对一种或多种非特异病原体的异常反应, 是遗传、环境与免疫共同作用的结果。川崎病以免疫系统异常激活为显著特征, 其机制涉及固有免疫和适应性免疫之间复杂的相互作用。目前研究明确了川崎病相关病理过程的免疫细胞类型, 但其特定的免疫发病机制仍未明确。该文从遗传、环境和免疫三个方面介绍了川崎病相关免疫机制的研究进展, 有助于预测标志物、治疗靶点的发现、疾病早期识别、个体化治疗及改善预后。Kawasaki disease is an acute systemic vasculitis that predominantly affects children under the age of 5 years.While the etiology remains unclear,it is thought to be an abnormal immune response to one or more non-specific pathogens in genetically predisposed individuals.This condition arises from the interplay between genetic susceptibility,environmental factors,and immune system dynamics.The disease is characterized by significant immune system activation,involving complex interactions between innate and adaptive immunity.Although recent studies have identified the immune cell types implicated in the pathology of Kawasaki disease,the specific immunopathogenic mechanisms remain unknown.This review explores the research advancements on the immunological mechanisms related to Kawasaki disease from three perspectives(genetics,environment,and immunity),which may be helpful in identifying valuable predictive biomarkers and therapeutic targets,facilitating early identification,individualizing treatment,and improving prognosis.

关 键 词：川崎病 免疫反应 机制 

分 类 号：R725.4[医药卫生—儿科]