川崎病冠状动脉病变动物模型研究进展  

Advances in animal models of coronary artery lesion in Kawasaki disease

作　　者：余俊弟 杨鹏晖 王晋[1] Yu Jundi;Yang Penghui;Wang Jin(Department of Pediatric Cardiology,Lanzhou University Second Hospital,Lanzhou 730030,China)

机构地区：[1]兰州大学第二医院小儿心血管科,730030

出　　处：《国际儿科学杂志》2024年第11期725-729,共5页International Journal of Pediatrics

基　　金：兰州市科学技术局科技计划项目(2023-ZD-77);兰州大学第二医院“萃英科技创新”计划项目(CY2022-BJ-04);兰州大学第二医院萃英学子科研培育计划项目(CYXZ2024-37)。

摘　　要：川崎病(Kawasaki disease,KD)是发生在儿童全身中小动脉的一种非特异性炎症, 其中部分病例伴有的冠状动脉损害, 近年来已经成为儿童获得性心脏病的主要原因之一。但至今国内外关于KD病理变化的分子机制尚未完全了解。因此, 建立一种与临床病理变化高度相似的动物模型以弥补临床取材的稀缺, 对于KD发病机制的研究意义重大。目前KD小鼠模型诱导剂包括干酪乳酸杆菌胞壁提取物、白色念珠菌水溶性多聚糖片段、白色念珠菌衍生物等, 该文对上述诱导剂建立的KD小鼠模型以及由血清或其他诱导剂所诱发的兔、幼猪、幼犬的KD冠状动脉损害的模型进行介绍, 其中涉及到的相关通路和炎症因子可能为KD早期诊断和靶向药物治疗研究提供新的思路。Kawasaki disease(KD)is a non-specific inflammation of small and medium-sized arteries in children.Some of these cases are accompanied by coronary artery damage,which has become one of the main causes of acquired heart disease in children in recent years.However,up to now,the molecular mechanism of mediating pathological changes of KD has not been fully understood at home and abroad.Therefore,the establishment of an animal model which is highly similar to the clinical pathological changes to make up for the scarcity of clinical samples is of great significance for the future study of the pathogenesis of KD.At present,KD mouse models inducers include Lactobacillus casei cell wall extract,Candida albicans water-soluble polysaccharide fragments,Candida albicans derivatives,and so on.This paper introduces the KD mouse models established by the above-mentioned inducers and the KD coronary artery damage models induced by serum or other causes in rabbits,young pigs and dogs.The related pathways and inflammatory factors involved may provide new ideas for early clinical diagnosis and targeted drug therapy of KD.

关 键 词：川崎病 冠状动脉损害 诱导剂 动物模型 

分 类 号：R725.4[医药卫生—儿科] R-332[医药卫生—临床医学]