肠道菌群失调与儿童高血压的研究进展  

Advances in gut microbiota dysbiosis and hypertension in children

作　　者：张治学 石琳 Zhang Zhixue;Shi Lin(Department of Cardiology,Capital Institute of Pediatrics,Peking University Teaching Hospital,Children's Hospital Capital Institute of Pediatrics,Beijing 100020,China)

机构地区：[1]北京大学首都儿科研究所教学医院、首都儿科研究所附属儿童医院心血管内科,100020

出　　处：《国际儿科学杂志》2024年第11期740-743,共4页International Journal of Pediatrics

基　　金：北京市科学技术委员会首都临床诊疗技术研究及转化应用项目(Z211100002921035);北京市卫生健康委员会首都卫生发展科研专项(首发2022-3-2105)。

摘　　要：近年来, 儿童高血压的发病率逐年增加。儿童高血压可引起肾脏、心血管、眼底等靶器官损害, 增加成年期高血压及心血管事件的风险, 需积极治疗。生活方式干预、降压药物是儿童高血压的主要治疗方案, 但部分患儿血压控制率仍较低。研究表明肠道菌群及其代谢产物对维持内环境稳态具有重要作用, 与儿童高血压等心血管疾病关联密切。高血压儿童存在肠道菌群失调, 通过补充益生菌等菌群疗法可以降低小鼠及受试者血压水平。该文从原发性高血压、继发性高血压、儿童肥胖、婴幼儿期肠道菌群紊乱与儿童高血压的关系进行综述, 为评估肠道菌群在儿童高血压治疗中的临床价值提供参考。The incidence of hypertension in children has increased year by year in recent years.Hypertension in children can cause target organ damages(mainly kidney,cardiovascular system,or optic fundus),which may increase the risk of hypertension and cardiovascular events in adulthood.Therefore,the appropriate management is necessary and important.Life style changes and antihypertensive medication are the primary treatment options for children with hypertension.However,the blood pressure control rate is still at a low level.Studies have shown that gut microbiota and its metabolites play important roles in maintaining the homeostasis of the body and are closely related to cardiovascular diseases such as hypertension in children.Children with hypertension often have gut microbiota dysbiosis,fortunately,supplementation of probiotics and other microflora therapy had been found to reduce blood pressure levels in mice and human subjects.This article thoroughly examines the connection between gut microbiota dysbiosis and pediatric hypertension,considering primary hypertension,secondary hypertension,obesity,and other relevant factors,providing valuable insights for further research on the clinical significance of gut microbiota in treating pediatric hypertension.

关 键 词：儿童 高血压 肠道菌群 

分 类 号：R725.4[医药卫生—儿科]