早发性抗核抗体阳性幼年特发性关节炎诊治进展  

Advances in the diagnosis and treatment of early onset antinuclear antibody positive juvenile idiopathic arthritis

作　　者：李会珍 屠志强[1] 曹兰芳[1] Li Huizhen;Tu Zhiqiang;Cao Lanfang(Department of Pediatrics,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai200001,China)

机构地区：[1]上海交通大学医学院附属仁济医院儿科,200001

出　　处：《国际儿科学杂志》2024年第11期772-775,共4页International Journal of Pediatrics

摘　　要：早发性抗核抗体阳性幼年特发性关节炎被作为一种单独类型进行分类,见于2018年儿科风湿病国际试验组织提出的新分类标准,该标准明显有别于2001年国际风湿病协会联盟的经典分类方法。早发性抗核抗体阳性幼年特发性关节炎被定义为6岁以前起病、不对称关节炎、高发慢性虹膜睫状体炎、抗核抗体阳性、与HLA-B27相关的疾病,好发于女童。早发性抗核抗体阳性幼年特发性关节炎的临床管理仍具有挑战性,而且对该病的临床认知度也有待提高。该文从早发性抗核抗体阳性幼年特发性关节炎的流行病学、病因与发病机制、临床表现及诊断标准、鉴别诊断、治疗、转归及预后等方面阐述相关进展,旨在提高临床医生的认识,同时提高早发性抗核抗体阳性幼年特发性关节炎的诊疗水平,有利于早期诊断与早期治疗,从而有助于改善预后。Early onset antinuclear antibody positive juvenile idiopathic arthritis is classified as a new separate type proposed by the International Experimental Organization for Pediatric Rheumatology in 2018,which differs from the classic classification method of the International Federation of Rheumatology Associations in 2001.Early onset antinuclear antibody positive juvenile idiopathic arthritis is defined by the onset before the age of 6 years,asymmetric arthritis,high incidence of chronic iridocyclitis,ANA positivity,and HLA-B27 related diseases,which are more common in girls.The clinical management of early onset antinuclear antibody positive juvenile idiopathic arthritis is challenging,and the awareness of this disease also needs to be improved.This article elaborates on the latest progress of early onset antinuclear antibody positive juvenile idiopathic arthritis in the aspects of epidemiology,etiology and pathogenesis,clinical manifestations and diagnostic criteria,differential diagnosis,treatment,outcome,and prognosis,in order to deepen the understanding of clinicians,improve the diagnosis and treatment level of this type of juvenile idiopathic artbritis,and make early diagnosis.

关 键 词：抗核抗体 幼年特发性关节炎 诊断 治疗 

分 类 号：R725.9[医药卫生—儿科]