SPECT及PET探针在特发性肺纤维化中的显像研究进展  

Progress in tracers for SPECT and PET imaging of idiopathic pulmonary fibrosis

作　　者：刘珺伊 石怡凡 邓晓云 朱小华 Liu Junyi;Shi Yifan;Deng Xiaoyun;Zhu Xiaohua(Department of Nuclear Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China)

机构地区：[1]华中科技大学同济医学院附属同济医院核医学科,武汉430030

出　　处：《中华核医学与分子影像杂志》2024年第12期758-763,共6页Chinese Journal of Nuclear Medicine and Molecular Imaging

基　　金：国家重点研发计划(2021YFC2500703)。

摘　　要：特发性肺纤维化(IPF)是一种病因不清的进行性纤维化性间质性肺病,主要临床表现为进行性加重的呼吸困难伴干咳,其典型病理特征为成纤维细胞的过度活化以及大量细胞外基质的沉积。IPF早期诊断困难,治疗选择有限且存在明显局限性,患者预后不良。SPECT和PET作为分子影像的先进代表,能够在解剖结构出现异常之前反映细胞功能异常,进而实现IPF早期诊断和治疗方案的优化。该文综述了IPF的分子影像靶点及相应的SPECT和PET探针的研究进展。Idiopathic pulmonary fibrosis(IPF)is a progressive fibrotic interstitial lung disease with an unclear etiology,characterized clinically by worsening dyspnea and dry cough.Its typical pathological features include excessive activation of fibroblasts and deposition of abundant extracellular matrix.Early diagnosis of IPF is challenging,treatment options are limited with significant constraints,and patients have a poor prognosis.SPECT and PET,as advanced representatives of molecular imaging,can reflect cellular functional abnormalities before anatomical structural abnormalities appear,thereby facilitating early diagnosis of IPF and optimization of treatment strategies,leading to improved prognosis.This review summarizes the research progress on molecular imaging targets and corresponding SPECT and PET probes in IPF.

关 键 词：特发性肺纤维化 分子探针 体层摄影术 发射型计算机 单光子 正电子发射断层显像术 发展趋势 

分 类 号：R563[医药卫生—呼吸系统] R817.4[医药卫生—内科学]