Systemic and dynamic immune landscape of Omicron-infected subjects treated with Lianhua Qingwen capsules  

作　　者：Shijun Chen Fuxiang Wang Yuanlong Lin Yinyin Xie Ruihong Zhang Juan Chen Niu Qiao Tong Yin Yun Tan Hai Fang Hongzhou Lu Zhu Chen Shanhe Yu Jiang Zhu Zhenhua Jia Saijuan Chen 

机构地区：[1]Shanghai Institute of Hematology,State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai,Collaborative Innovation Center of Hematology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China [2]Department of Infectious Diseases,National Clinical Research Centre for Infectious Diseases,the Third People's Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology,Shenzhen 518112,China [3]Hebei Academy of Integrated Traditional Chinese and Western Medicine,Shijiazhuang 050035,China [4]National Key Laboratory for Innovation and Transformation of Luobing Theory,Shijiazhuang 050035,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第11期5074-5078,共5页药学学报（英文版）

基　　金：Key Project of National Natural Science Foundation of China(82130123);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202206,China).

摘　　要：To the Editor:The COVID-19 has represented an unexpected global public health challenge due to the profound immune evasion and transmission capabilities of the responsible virus SARS-CoV-21,being in great short of effective prophylactic and curative methods.Lianhua Qingwen(LHQW)capsule,a traditional Chinese medicine(TCM)formula,is officially included in China's COVID-19 treatment guidelines and has shown antiviral activity in vitro and in vivo.Recent clinical trials have shown that LHQW can alleviate symptoms and accelerate recovery in Omicron-infected patients2.The immune pathology of COVID-19 involves a complex interplay between virus-induced injuries and multifactorial immune responses.However,a comprehensive analysis of the immunological basis of LHQW's effects in Omicron-infected subjects is still lacking.

关 键 词：COVID-19 LHQW capsule Chinese traditional medicine Immune landscape 

分 类 号：R96[医药卫生—药理学]