Heterologous biosynthesis of saponin adjuvants from Quillaja saponaria:A symbolic achievement in metabolic engineering  

作　　者：Weiqiang Chen Zhichao Xu Wei Sun 

机构地区：[1]State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China [2]Key Laboratory of Beijing for Identification and Safety Evaluation of Chinese Medicine,Institute of Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China [3]College of Life Science,Northeast Forestry University,Harbin 150040,China

出　　处：《Acta Pharmaceutica Sinica B》2024年第12期5518-5520,共3页药学学报（英文版）

摘　　要：Heterologous production of pharmaceutically important plant nat-ural products(PNPs)in heterologous hosts is an attractive strategy for the sustainable use of the resources bestowed by nature.Over the past two decades,a plethora of structurally divergent valuable PNPs including alkaloids,terpenoids,and phenylpropanoids have been synthesized in heterologous hosts via manipulating endoge-nous and/or heterologous genes that range from single digit to dozens^(1,2).

关 键 词：QS-21 QS-7 Plant natural products(PNPs) Heterologous biosynthesis 

分 类 号：R943[医药卫生—药剂学]