福建省成人慢性肾脏病流行特征及其与血脂异常关系研究  

Epidemiological characteristic of chronic kidney disease in adults and relationship between chronic kidney disease and dyslipidemia in adults of Fujian Province

作　　者：尹艳榕 林修全[1] 陈铁晖[1] 李晓庆[1] 黄少芬[1] 章叶发[1] 钟文玲 YIN Yanrong;LIN Xiuquan;CHEN Tiehui;LI Xiaoqing;HUANG Shaofen;ZHANG Yefa;ZHONG Wenling(Fujian Provincial Center for Disease Control and Prevention,Fuzhou,Fujian Province 350001,China)

机构地区：[1]福建省疾病预防控制中心地方病及慢性非传染性疾病防治所,福建省福州350001

出　　处：《中国慢性病预防与控制》2024年第11期837-842,共6页Chinese Journal of Prevention and Control of Chronic Diseases

基　　金：福建省科技厅引导性项目(2020Y0060);福建省卫生健康科技计划项目资助(2020QNB016)。

摘　　要：目的 了解福建省成人慢性肾脏病(CKD)患病情况及其与血脂异常的关系,为CKD的防治提供依据。方法 数据来源于2018年福建省成人慢性病及危险因素监测,采用多阶段分层整群随机抽样方法,在10个监测点选取6 019例18岁及以上常住居民作为研究对象。利用复杂抽样加权法估计福建省CKD患病率,采用基于复杂抽样设计的Rao-Scottχ^(2)检验和survey logistic回归系数的假设检验进行加权率差异的比较和趋势性检验。采用SAS 9.4软件进行单因素和多因素logistic回归分析。结果 福建省成人CKD加权患病率为8.74%,男性患病率为9.02%,女性患病率为8.44%。多因素分析结果显示,60岁及以上(与18~44岁年龄组相比OR=3.52)、高血压(OR=2.54)、糖尿病(OR=1.77)、血脂异常(OR=1.45)与CKD患病高风险相关,低体质量(OR=0.37)与CKD患病低风险相关,均有统计学意义(P<0.05)。各类血脂异常与CKD关联的多因素logistic回归分析结果显示,调整混杂因素后,高胆固醇血症(OR=1.53)、高低密度脂蛋白胆固醇血症(OR=1.39)与CKD患病高风险相关(P<0.05)。结论 福建省成人CKD患病率处于较高流行水平,应重点关注中老年人群以及患有高血压、糖尿病、血脂异常等慢性疾病相关人群。高胆固醇血症者和高低密度脂蛋白血症者患CKD的风险较高,需采取个体化干预措施,以期进一步降低CKD患病风险。Objective To understand the prevalence and relationship with dyslipidemia of chronic kidney disease(CKD)in adults of Fujian Province,and provide the basis for prevention and treatment of CKD.Methods Data was from the Fujian Chronic Disease and Risk Factors Surveillance of adults in 2018.The multi-stage stratified cluster random sampling method was used to select 6019 permanent residents(≥18 years old)from 10 monitoring sites as the subjects.Weighted estimation of complex sampling was used to analyze the morbidity of CKD in Fujian Province.Rao-Scott χ^(2) test based on a complex sampling design and hypothesis test on the survey logistic regression coefficients were used to compare the weighted rate difference and to test trend.Univariate and multifactorial logistic regress were used to analye the data.The used software was SAS 9.4.Results The weighted morbidity of adult CKD in Fujian Province was 8.74%(male:9.02%,female:8.44%).The results of multiple factor analysis showed that age≥60 years old(as compared with 18-44 years old group,OR=3.52),hypertension(OR=2.54),diabetes(OR=1.77),dyslipidemia(OR=1.45)and dyslipidemia(OR=1.45)were related with high risk of CKD.Low weight was related with low risk of CKD(P<0.05).Multivariate logistic regression analysis of the association of dyslipidemia with CKD showed that after adjusting the confounding factors,hypercholesterolemia(OR=1.53)and high low-density lipoprotein cholesterol(OR=1.39)were related with high risk of CKD,P<0.05.Conclusion The chronic kidney disease morbidity of adults in Fujian Province is high.It should pay attention to middle-aged and elderly people and people with hypertension,diabetes and dyslipidemia chronic diseases.The patients with hypercholesterolemia and high low-density lipoprotein cholesterol have the high risk of CKD.The individualized intervention measures should be taken to further reduce the risk of CKD.

关 键 词：慢性肾脏病 高甘油三酯血症 高胆固醇血症 高低密度脂蛋白胆固醇血症 低高密度脂蛋白胆固醇血症 

分 类 号：R181.3[医药卫生—流行病学]