Variants within KIF5B are associated with weight loss through mitochondrial transport alteration in sheep  

作　　者：Jieran Chen Haitao Wang Tingting Li Yuting Zhang Yan Chen Na Zhang Hengqian Yang Zhichao Zhang Ziyuan Duan Xia Li Daxiang Wang Zhixiong He Fan Hu Jianfeng Gao Runlin Z.Ma Xun Huang Qiuyue Liu 

机构地区：[1]College of Life Sciences,Shihezi University,Shihezi,Xinjiang 832000,China [2]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China [3]Jiangsu Qianbao Animal Husbandry Co.,Ltd,Yancheng,Jiangsu 224050,China [4]CAS Key Laboratory for Agro-Ecological Processes in Subtropical Region,National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production,Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process,Institute of Subtropical Agriculture,Chinese Academy of Sciences,Changsha,Hunan 410125,China

出　　处：《Journal of Genetics and Genomics》2024年第12期1513-1516,共4页遗传学报（英文版）

基　　金：supported by the Strategic Priority Research Program of Chinese Academy of Sciences(XDA24030205 and XDA26040303);Biological Breeding-National Science and Technology Major Project(2023ZD0407106 and 2023ZD0406805)。

摘　　要：Sheep(Ovis aries)is a key source of meat for humans,and their weight loss significantly impacts meat production.Although a few causative genes related to weight loss have been identified,the inheritance mechanisms and genetic pathways involved remain to be further elucidated.Artificial selection can effectively fix substantial mutations in these genes,enhancing meat production in sheep.Kinesin family member 5B(KIF5B)is a member of the kinesin-1protein family,which is made up of two kinesin heavy chains(KHCs)and two kinesin light chains(KLCs).Each kinesin motor head features an ATP pocket and a microtubule-binding domain,enabling it to function as a molecular motor(Hirokawa et al.,2009).

关 键 词：CHAINS WEIGHT SHEEP 

分 类 号：S826.2[农业科学—畜牧学]