Active targeted drug delivery system constructed from functionalized pillararenes for chemo/photodynamic synergistic therapy  

作　　者：Bing Lu Yuying Huang Jiachen Xia Yong Yao 

机构地区：[1]College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019,China

出　　处：《Frontiers of Chemical Science and Engineering》2024年第11期391-398,共8页化学科学与工程前沿（英文版）

基　　金：National Natural Science Foundation of China(Grant No.32301184);Universities Natural Science Research Project of Jiangsu Province(Grant No.23KJB150027).

摘　　要：Nowadays,although functionalized pillararenes have been widely designed to be used in drug delivery system,targeted group modified pillararenes have been seldom reported and used in tumor multimodal therapy.Herein,a functionalized pillararene with a polyethylene glycol chain and triphenylphosphonium cation WP5-PEG-TPP was designed and synthesized.Subsequently,an active targeted drug delivery system was constructed based on its host-guest interactions with a newly designed porphyrin derivative,Py-Por.The experimental results demonstrated that this drug delivery system has exhibited excellent targeting ability against tumor cells,but interestingly it could not enter normal cells.After loading the hypoxia-activated prodrug tirapazamine,the prepared nanodrugs displayed high lethality to tumor cells due to their chemo/photodynamic synergistic therapy capability,but negligible toxicity to normal cells.Preliminary therapeutic mechanism study elucidated the synergistic therapy process.

关 键 词：durg delivery system active targeting pillararene chemo photodynamic synergistic therapy 

分 类 号：TQ460.1[化学工程—制药化工] R943[医药卫生—药剂学]