Environmental sources,fate,toxicological effects,and health risks of copper pyrithione:an overview  

作　　者：Can Tang Xian Qin Wenlong Huang Sutapa Debi Zonghang Zhang Jiahua Guo Wenhua Liu Jiezhang Mo 

机构地区：[1]Guangdong Provincial Key Laboratory of Marine Disaster Prediction and Prevention,Shantou University,Shantou 515063,China [2]State Key Laboratory of Marine Pollution,City University of Hong Kong,Hong Kong,China [3]Department of Forensic Medicine,Shantou University Medical College,Shantou 515041,China [4]Shaanxi Key Laboratory of Earth Surface System and Environmental Carrying Capacity,College of Urban and Environmental Sciences,Northwest University,Xi’an 710127,China

出　　处：《Frontiers of Environmental Science & Engineering》2024年第11期1-20,共20页环境科学与工程前沿（英文）

基　　金：supported by Shantou University STU Scientific Research Initiation Grant(NTF23010);the Program for University Innovation Team of Guangdong Province(2022KCXTD008);the Science and Technology Planning Project of Guangdong Province(2021B1212050025).

摘　　要：Copper pyrithione(CuPT)is an alternative to tributyltin that is widely used as an antifoulant and biocide in paint for ship hulls,fishing nets,and other marine environmental facilities.It gradually leaches from antifouling coatings into the aquatic environment,posing health risks to aquatic organisms.In recent years,there have been increasing concerns regarding the impacts of CuPT and its degradation products on organisms,as well as the associated health risks.Although the ecotoxicity of CuPT and its degradation products in various species has been studied,there are no comprehensive reviews in the literature that have collated and interpreted these data.This review provides a comprehensive summary of the ecotoxicological effects of CuPT and its degradation products on microorganisms,plants,invertebrates,fish,and mammals.CuPT and its degradation products can affect the light utilization of plants,thereby altering primary production in ecosystems.It can disrupt cell membranes,antioxidant capacity,and cellular pH gradients in animals,leading to developmental toxicity,deformities,morphological damages,endocrine disruption,reproductive toxicity,hepatotoxicity,and neurotoxicity.Mitochondria are believed to be the primary target of CuPT-induced toxicity in aquatic animals;however,further investigations are warranted to reveal the long-term(e.g.,multigenerational and transgenerational)impacts and associated molecular mechanisms of CuPT and its degradation products—particularly at environmentally realistic levels.This will facilitate a more comprehensive understanding of the health effects(both in terms of toxicity and hormesis)and environmental risks of CuPT and its degradation products,facilitating more effective regulation and mitigation.

关 键 词：Copper pyrithione ECOTOXICITY Environmental fate Ecological risk assessment Review 

分 类 号：X503[环境科学与工程—环境工程]