Application of nanozymes in problematic biofilm control:progress,challenges and prospects  

作　　者：Junzheng Zhang Tong Dou Yun Shen Wenrui Wang Luokai Wang Xuanhao Wu Meng Zhang Dongsheng Wang Pingfeng Yu 

机构地区：[1]College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China [2]Innovation Center of Yangtze River Delta,Zhejiang University,Jiashan 314100,China [3]Department of Civil and Environmental Engineering,The George Washington University,Washington,DC 20052,USA

出　　处：《Frontiers of Environmental Science & Engineering》2024年第11期65-84,共20页环境科学与工程前沿（英文）

基　　金：supported by the National Natural Science Foundation of China(Nos.52030003 and 32302244);the National Key Research and Development Program of China(Nos.2022YFC3203805 and 2022YFC3704700);the Starry Night Science Fund of Zhejiang University Shanghai Institute(China)for Advanced Study.

摘　　要：Current microbial control strategies face challenges in keeping up with the escalation of microbial problems due to the presence of biofilms.Therefore,there is an urgent need to develop effective and robust strategies to control problematic biofilms in water treatment and reuse systems.Nanozymes,which have intrinsic biocatalytic activity and broad antibacterial spectra,hold promise for controlling resilient biofilms.This review summarizes the milestones of nanozyme studies and their applications as antibiofilm agents.The mechanisms behind the antibacterial,quorum quenching,and depolymerizing properties of nanozymes with different enzyme activities are discussed.Notably,the surface and composition of nanozymes are crucial for their efficacy in biofilm control;thus,rationally designed nanozymes can increase their effectiveness.Additionally,the challenges of nanozymes as antibiofilm agents in realistic scenarios are investigated along with proposed strategies to overcome these challenges.Prospects of nanozyme-based biofilm control,such as machine learning-assisted nanozyme design,are also discussed.Overall,this review highlights the potential of nanozymes as antibiofilm agents and provides insights into the future design of nanozymes for biofilm control.

关 键 词：Nanozymes BIOFILM Antibacterial mechanisms Rational design Machine learning 

分 类 号：TB383.1[一般工业技术—材料科学与工程]