脑卒中后脑心交互作用及器官保护的研究进展  

Research advances in post-stroke brain-heart interaction and organ protection

作　　者：吴露玲 王蓉[1,2,3] 王婷婷[1,2,3] Wu Luling;Wang Rong;Wang Tingting(Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Institute of Anesthesia and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Key Laboratory of Anesthesiology and Resuscitation(Huazhong University of Science and Technology),Ministry of Education,Wuhan 430022,China)

机构地区：[1]华中科技大学同济医学院附属协和医院麻醉科,武汉430022 [2]华中科技大学同济医学院附属协和医院麻醉与危重病研究所,武汉430022 [3]麻醉复苏教育部重点实验室(华中科技大学),武汉430022

出　　处：《国际麻醉学与复苏杂志》2024年第11期1190-1194,共5页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81770824)。

摘　　要：脑卒中引发的心血管系统紊乱对于阐述脑-心相互作用的复杂性具有至关重要的科研与临床价值。广泛的临床数据支持脑卒中可诱发多样的心血管功能障碍,包括但不限于心律不齐、心脏泵血功能受损等,这些并发症与患者病死率的增加密切相关。所谓脑-心轴,指的是心脏与大脑间所构成的复杂双向功能网络。文章旨在综合近年来的体外实验研究成果,阐述脑卒中后大脑与心脏相互作用的复杂病理生理学机制,包括下丘脑-垂体-肾上腺(HPA)轴、交感与副交感神经活动增强、免疫炎症反应以及肠道菌群失调,并就脑卒中后心脑器官的保护策略提出建议,从而提高患者的生存率。Stroke-induced cardiovascular dysregulation holds significant scientific and clinical relevance in elucidating the complexity of brain-heart interactions.Extensive clinical data substantiate that stroke can precipitate a spectrum of cardiovascular dysfunctions,including,but not limited to,arrhythmias,impaired myocardial pump function,which are closely associated with increased mortality rates.The term"brain-heart axis"refers to the intricate bidirectional functional network interconnecting the heart and the brain.This review aims to'synthesize recent findings from in vitro studies to delineate the complex pathophysiological mechanisms of brain-heart interaction after cerebral ischemic stroke,including hypothalamic-pituitary-adrenal(HPA)axis,enhanced sympathetic and parasympathetic activity,immunoinflammatory responses,and intestinal flora dysregulation,and to propose protective strategies for cardio-cerebral organs following stroke,so as to improve the survival of the patients.

关 键 词：脑-心轴 脑卒中 心血管功能障碍 器官保护 

分 类 号：R614[医药卫生—麻醉学]