清金化痰益肺汤联合常规西药治疗支气管肺炎临床研究  

Clinical Study on Qingjin Huatan Yifei Decoction Combined with Routine WesternMedicine for Bronchopneumonia

作　　者：孟伟峰 何月敏 MENG Weifeng;HE Yuemin(Shaoxing 7th People's Hospital,Shaoxing Zhejiang 312000,China)

机构地区：[1]绍兴市第七人民医院,浙江绍兴312000

出　　处：《新中医》2024年第13期92-96,共5页New Chinese Medicine

摘　　要：目的:观察清金化痰益肺汤联合常规西药治疗支气管肺炎的临床疗效。方法:选择支气管肺炎患儿88例,按随机数字表法分为对照组和观察组各44例。对照组给予常规西药治疗,观察组在对照组基础联合清金化痰益肺汤治疗。评价2组临床疗效,比较2组治疗前后中医证候评分、肺功能指标、免疫功能指标及血清炎症因子水平,统计2组不良反应发生率。结果:观察组总有效率为95.45%,高于对照组79.55%(P<0.05)。治疗后,2组主症评分、次症评分及总积分较治疗前降低(P<0.05),且观察组主症评分、次症评分及总积分均低于对照组(P<0.05)。治疗后,2组用力肺活量(FVC)、第1秒用力呼气容积(FEV_(1))、第1秒用力呼气容积占用力肺活量百分比(FEV_(1)/FVC)较治疗前升高(P<0.05),且观察组FVC、FEV_(1)、FEV_(1)/FVC高于对照组(P<0.05)。治疗后,2组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)水平较治疗前升高(P<0.05),且观察组IgA、IgM、IgG水平高于对照组(P<0.05)。治疗后,2组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、C-反应蛋白(CRP)水平较治疗前降低,干扰素-γ(IFN-γ)水平较治疗前升高(P<0.05);且观察组血清TNF-α、IL-8、CRP水平低于对照组,IFN-γ水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:清金化痰益肺汤联合常规西药治疗支气管肺炎可有效改善患者临床症状,改善呼吸功能并提高免疫功能,减轻气道炎症反应,降低不良反应发生率。Objective:To observe the clinical effect of Qingjin Huatan Yifei Decoction combined with routine western medicine for bronchopneumonia.Methods:A total of 88 cases of children with bronchopneumonia were selected and divided into the control group and the observation group according to the random number table method,with 44 cases in each group.The control group was treated with routine western medicine,and the observation group was additionally treated with Qingjin Huatan Yifei Decoction based on the treatment of the control group.The clinical effects in the two groups were evaluated;traditional Chinese medicine syndrome scores,lung function indexes,immune function indexes and serum inflammatory factor levels were compared before and after treatment between the two groups;the incidence rate of adverse reactions was analyzed.Results:The total effective rate was 95.45%in the observation group,higher than that of 79.55%in the control group(P<0.05).After treatment,the scores of main and secondary symptoms and the total scores in the two groups were decreased when comparedwith those before treatment(P<0.05),and the scores of main and secondary symptoms and the totalscores in the observation group were lower than those in the control group(P<0.05).After treatment,forced vital capacity(FVC),forced expiratory volume in the first second(FEV_(1))and the percentage of forcedexpiratory volume in the first second to forced vital capacity(FEV_(1)/FVC)in the two groups were increasedwhen compared with those before treatment(P<0.05),and FVC,FEV_(1)and FEV_(1)/FVC in the observationgroup were higher than those in the control group(P<0.05).After treatment,the levels of immunoglobulinA(IgA),immunoglobulin G(IgG)and immunoglobulin M(IgM)in the two groups were increased whencompared with those before treatment(P<0.05),and the levels of IgA,IgM and IgG in the observationgroup were higher than those in the control group(P<0.05).After treatment,the levels of tumor necrosisfactor-α(TNF-α),interleukin-8(IL-8)and C-reactive protein(CRP)in

关 键 词：支气管肺炎 清金化痰益肺汤 肺功能 中医证候评分 炎症因子 免疫功能 不良反应 

分 类 号：R563.1[医药卫生—呼吸系统]