湿热壅遏汤联合盐酸莫西沙星片治疗急性盆腔炎湿毒壅盛证临床研究  

Clinical Study on Shire Yong'e Decoction Combined with Moxifloxacin HydrochlorideTablets for Acute Pelvic Inflammatory Disease with Excessive Dampness ToxinSyndrome

作　　者：杨燕婷 张菁云 YANG Yanting;ZHANG Jingyun(Department of Chinese Medicine Gynecology,Deqing Hospital of Traditional Chinese Medicine,Deqing Zhejiang 313200,China)

机构地区：[1]德清县中医院中医妇科,浙江德清313200

出　　处：《新中医》2024年第13期137-141,共5页New Chinese Medicine

摘　　要：目的:观察湿热壅遏汤联合盐酸莫西沙星片治疗急性盆腔炎(APID)湿毒壅盛证的临床疗效。方法:采用随机数字表法将84例APID患者分为对照组和观察组各42例,对照组口服盐酸莫西沙星片,观察组在对照组基础上加服湿热壅遏汤,2组均连续治疗2周。评价2组临床疗效,比较2组治疗前后的中医证候评分、血清炎症指标、血液流变学指标及免疫学指标,观察不良反应发生情况。结果:观察组总有效率为92.86%,高于对照组78.57%,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分较治疗前降低(P<0.05),且观察组中医证候积分低于对照组(P<0.05)。治疗后,2组血清血清C-反应蛋白(CRP)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)水平较治疗前降低(P<0.05),且观察组CRP、IL-8、TNF-α水平低于对照组(P<0.05)。治疗后,2组高切全血黏度、低切全血黏度、血浆黏度较治疗前降低(P<0.05),且观察组高切全血黏度、低切全血黏度、血浆黏度低于对照组(P<0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)较治疗前升高,CD8^(+)较治疗前降低(P<0.05);且观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,CD8^(+)低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:湿热壅遏汤联合盐酸莫西沙星片在临床应用中可有效改善APID湿毒壅盛证患者的临床症状及血液流变学指标,减轻炎症反应,提高免疫力。Objective:To observe the clinical effect of the therapy of Shire Yong'e Decoction combined with Moxifloxacin Hydrochloride Tablets on acute pelvic inflammatory disease(APID)with excessive dampness toxin syndrome.Methods:A total of 84 APID patients were divided into the control group and the observation group according to the random number table method,with 42 cases in each group.The control group was given oral administration of Moxifloxacin Hydrochloride Tablets,and the observation group was additionally treated with Shire Yong'e Decoction based on the treatment of the control group.The two groups were treated for two weeks.The clinical effects in the two groups were evaluated;the traditional Chinese medicine syndrome scores and levels of serum inflammation markers,hemorheology indexes and immune indexes were compared before and after treatment between the two groups;the incidence of adverse reactions was observed.Results:The total effective rate was 92.86%in theobservation group,higher than that of 78.57%in the control group,the difference being significant(P<0.05).After treatment,the traditional Chinese medicine syndrome scores in the two groups weredecreased when compared with those before treatment(P<0.05),and the above score in the observationgroup was lower than that in the control group(P<0.05).After treatment,the levels of serum C-reactiveprotein(CRP),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)in the two groups were decreasedwhen compared with those before treatment(P<0.05),and the levels of CRP,IL-8 and TNF-αin theobservation group were lower than those in the control group(P<0.05).After treatment,the high-shearwhole blood viscosity,low-shear whole blood viscosity and blood viscosity in the two groups weredecreased when compared with those before treatment(P<0.05),and the high-shear whole bloodviscosity,low-shear whole blood viscosity and blood viscosity in the observation group were lower thanthose in the control group(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+

关 键 词：急性盆腔炎 湿毒壅盛证 湿热壅遏汤 炎症因子 免疫功能 

分 类 号：R711.33[医药卫生—妇产科学]