基于血清降钙素原水平指导的抗菌治疗在老年肺部感染患者中的应用效果  

Application Effect of Antimicrobial Therapy Guided by Serum Procalcitonin Level in Elderly Patients with Pulmonary Infection

作　　者：吕珺 Lyu Jun(Xiangcheng District No.3 People's Hospital,Suzhou 215134,Jiangsu Province,China)

机构地区：[1]苏州市相城区第三人民医院,江苏苏州215134

出　　处：《中国社区医师》2024年第36期26-28,共3页Chinese Community Doctors

摘　　要：目的:分析基于血清降钙素原(PCT)水平指导的抗菌治疗在老年肺部感染患者中的应用效果。方法:选取苏州市相城区第三人民医院2023年1月—2024年1月收治的80例老年肺部感染患者作为研究对象,根据随机数字表法分为对照组和观察组,各40例。对照组给予常规抗菌治疗,观察组给予基于PCT指导的抗菌治疗。比较两组治疗效果、抗菌药物使用时间、住院时间、药物费用、重复感染发生率及炎症指标。结果:两组治疗总有效率比较,差异无统计学意义(P>0.05)。观察组抗菌药物使用时间、住院时间短于对照组,药物费用少于对照组(P<0.05)。观察组重复感染发生率低于对照组(P=0.031)。治疗前,两组白细胞计数(WBC)、C反应蛋白(CRP)、红细胞沉降率(ESR)水平比较,差异无统计学意义(P>0.05);治疗后,两组WBC、CRP、ESR水平均比治疗前低(P<0.05),但两组间WBC、CRP、ESR水平比较,差异无统计学意义(P>0.05)。结论:基于血清PCT水平指导的抗菌治疗在老年肺部感染患者中的应用效果显著,能够缩短抗菌药物使用时间和住院时间,减少药物费用,降低重复感染发生率。Objective:To analyze the application effect of antimicrobial therapy guided by serum procalcitonin(PCT)level in elderly patients with pulmonary infection.Methods:A total of 80 elderly patients with pulmonary infection admitted to Xiangcheng District No.3 People's Hospital in Suzhou City from January 2023 to January 2024 were selected as the study subjects.They were divided into control group and observation group by random number table method,with 40 cases in each group.The control group received conventional antimicrobial therapy,while the observation group received antimicrobial therapy guided by PCT.The treatment effect,duration of antimicrobial use,length of hospital stay,drug cost,incidence of repeated infection and inflammatory indicators were compared between the two groups.Results:There was no significant difference in the total effective rate of treatment between the two groups(P>0.05).The duration of antimicrobial use and the length of hospital stay in the observation group were shorter than those in the control group,and the drug cost in the observation group was lower than that in the control group(P<0.05).The incidence of repeated infection in the observation group was lower than that in the control group(P=0.031).Before treatment,there was no significant difference in the levels of white blood cell count(WBC),C-reactive protein(CRP)and erythrocyte sedimentation rate(ESR)between the two groups(P>0.05).After treatment,the levels of WBC,CRP and ESR in the two groups were lower than those before treatment(P<0.05),but there was no significant difference in the levels of WBC,CRP and ESR between the two groups(P>0.05).Conclusion:Antimicrobial therapy guided by serum PCT level has a significant effect in elderly patients with lung infection,and can shorten the time of antimicrobial use and the length of hospital stay,reduce the drug cost and the incidence of repeated infection.

关 键 词：肺部感染 老年 降钙素原 抗菌治疗 

分 类 号：R541.6[医药卫生—心血管疾病] R563.1[医药卫生—内科学]