基于VOSviewer和CiteSpace全球心血管领域细胞焦亡的知识图谱分析  

Knowledge graph analysis on pyroptosis in global cardiovascular field based on VOSviewer and CiteSpace

作　　者：任高灿 刘奕呈 迟显苏 马晓昌[1,2] Ren Gaocan;Liu Yicheng;Chi Xiansu;Ma Xiaochang(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;不详)

机构地区：[1]中国中医科学院西苑医院,北京100091 [2]国家中医心血管病临床医学研究中心,北京100091

出　　处：《中国循证心血管医学杂志》2024年第12期1409-1415,共7页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：国家重点研发计划项目(2018YFC1707404);中国中医科学院科技创新工程(CI2021A00904)。

摘　　要：细胞焦亡是一种由gasdermin家族蛋白介导的溶解性炎症性程序性细胞死亡方式。细胞焦亡可能参与多种心血管疾病(CVDs)的发病机制,如动脉粥样硬化、心肌梗死、心力衰竭等。然而,关于细胞焦亡在CVDs中的全球研究趋势和热点尚未进行文献计量学分析。从Web of Science Core Collection(WoSCC)中检索了建库至2023年关于细胞焦亡在CVDs中的所有论著。我们使用文献计量学方法和软件工具(CiteSpace和VOSviewer)对发文量、国家/地区、机构、作者、关键词等数据进行分析和可视化。共有1958篇文献被纳入分析。发表量呈现逐年增长的趋势。中国和美国分别是最具生产力和影响力的国家。哈尔滨医科大学和Antonio Abbate分别是最多产的机构和作者。文献关键词主要集中:“nlrp3 inflammasome”,“cardiovascular diseases”,“inflammation”,“oxidative stress”,“activation”,“ischemia/reperfusion injury”,“myocardial infarction”等方面。通过关键词出现的时间顺序,我们推测心房颤动和心脏毒性是CVDs研究的未来方向。本研究系统说明了细胞焦亡在CVDs中的研究现状和发展方向,为后续相关疾病的治疗和实验研究提供新思路和新方法,推动该领域的进展。Pyroptosis is a soluble inflammatory programmed cell death mode mediated by gasdermin family of proteins.Pyroptosis may take part in the pathogenesis of various cardiovascular diseases(CVD),including atherosclerosis(AS),myocardial infarction(MI),and heart failure(HF).However,a bibliometric analysis on global research trends and hotspots for pyroptosis in CVD has yet to be reported.A systematic search for relevant literature on pyroptosis in CVD was conducted on the database of Web of Science Core Collection(WoSCC)to identify articles published from the inception of the database until 2023.Data analysis and visualization were performed with regard to publication volume,country/region,institute,author,journal,keywords and co-citation by using bibliometric methods and software tools(CiteSpace and VOSviewer).A total of 1958 studies were selected for analysis.The number of publications has steadily increased over the years.China and the United States are the most productive and influential countries.Harbin Medical University is the institution with the highest number of articles,while Antonio Abbate is the author with the most publications.The most frequent keywords included“NLRP3 inflammasome”,“cardiovascular diseases”,“inflammation”,“oxidative stress”,“activation”,“ischemia/reperfusion injury”,“myocardial infarction”,and“atherosclerosis”.Based on the chronological appearance of keywords,AF and cardiotoxicity were postulated as future research directions in CVD.This study presents a comprehensive overview of the current state of researches on pyroptosis in CVD,along with future perspectives.Additionally,it elucidates the collaborative networks established among nations,authors and institutions in this field.

关 键 词：细胞焦亡 心血管疾病 文献计量学 CITESPACE VOSviewer 

分 类 号：R4[医药卫生—临床医学]