血清sST2、syndecan-1水平对心房颤动患者主要心血管事件的预测价值  

The predictive value of serum sST2 and syndecan-1 levels for major cardiovascular events in patients with atrial fibrillation

作　　者：姜姝 郭江宏[3] 赵忠平[3] 盛红专[2] Jiang Shu;Guo Jianghong;Zhao Zhongping;Sheng Hongzhuan(School of Medicine,Nantong University,Nantong,Jiangsu 226001,China;不详)

机构地区：[1]南通大学医学院,南通226007 [2]南通大学附属医院心血管内科,南通226001 [3]如皋市人民医院心血管内科,如皋226500

出　　处：《中国循证心血管医学杂志》2024年第12期1441-1444,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

基　　金：江苏省医院协会2020年度医院管理创新研究课题项目(JSYGY-3-2020-159)。

摘　　要：目的探究血清可溶性致癌抑制因子2(sST2)、多配体蛋白聚糖1(syndecan-1)水平对心房颤动(AF)患者主要心血管事件(MACE)的预测价值。方法选取2021年6月至2023年6月于南通大学附属医院心血管内科收治的100例AF患者为观察组,随后进行6个月随访,根据患者是否出现MACE分为预后不良组(n=31)和良好组(n=69);另选取100例同期本院体检的健康者为对照组。比较观察组和对照组血清中sST2、syndecan-1的水平,多因素Logistic回归分析AF患者发生MACE的影响因素,ROC曲线分析血清sST2、syndecan-1水平对AF患者发生MACE的预测价值。结果与对照组相比,预后不良组和良好组血清sST2、syndecan-1水平明显升高(P<0.05);与良好组相比,预后不良组患者的年龄、性别、体质指数(BMI)、吸烟史、高血压史、糖尿病史以及血清白细胞介素-6(IL-6)、同型半胱氨酸(Hcy)水平均无明显差异(P>0.05),而血清C反应蛋白(CRP)、sST2、syndecan-1水平及饮酒史占比明显升高(P<0.05);多因素Logistic回归分析显示血清sST2、syndecan-1水平及饮酒史为AF患者发生MACE的影响因素(P<0.05);血清sST2、syndecan-1水平预测AF患者发生MACE的曲线下面积(AUC)分别为0.829、0.824,二者联合预测的AUC为0.921,二者联合预测优于各自单独预测(Z二者联合-sST2=1.991、Z二者联合-syndecan-1=1.996,P=0.047、P=0.046),二者联合预测的敏感度为80.65%,特异性为94.20%。结论AF患者血清sST2、syndecan-1水平上调,且sST2、syndecan-1水平及饮酒史为患者发生MACE的影响因素,二者联合对AF患者发生MACE具有较高的预测价值。Objective To investigate the predictive value of serum soluble suppression of tumorigenicity 2(sST2)and syndecan-1 levels for major adverse cardiovascular events(MACE)in patients with atrial fibrillation(AF).Methods One hundred AF patients treated in the Department of Cardiovascular Medicine in the Affiliated Hospital of Nantong University from June 2021 to June 2023 were enrolled as the observation group,and carried out a 6-month follow-up.The patients were separated into a poor prognosis group(31 cases)and a good group(69 cases)based on whether they had MACE.Meantime,another 100 healthy individuals who experienced physical check ups in our hospital were selected as the control group.The serum levels of sST2 and syndecan-1 in the observation group and the control group were compared.Multivariate logistic regression was applied to analyze the influencing factors of MACE in AF patients.ROC curve was applied to analyze the predictive value of serum sST2 and syndecan-1 levels for MACE in AF patients.Results Compared with the control group,the serum levels of sST2 and syndecan-1 were significantly increased in the poor prognosis group and the good prognosis group(P<0.05).Compared with the good group,there was no obvious difference in age,gender,body mass index(BMI),smoking history,hypertension history,diabetes history,and the serum levels of interleukin-6(IL-6)and homocysteine(Hcy)in the poor prognosis group(P>0.05),the serum levels of C-reactive protein(CRP),sST2,syndecan-1 and the proportion of drinking history were higher in the poor prognosis group(P<0.05).The serum levels of sST2 and syndecan-1,and the history of alcohol consumption were influencing factors for the occurrence of MACE in patients(P<0.05).The area under the curve(AUC)of serum sST2 and syndecan-1 levels in predicting MACE in AF patients was 0.829 and 0.824,respectively,the AUC predicted by the combination of the two was 0.921.Combined prediction of both is superior to predicting each individually(Zcombination-sST2=1.991,Zcombination-syndecan-1=1.99

关 键 词：心房颤动 可溶性致癌抑制因子2 多配体蛋白聚糖1 主要心血管事件 

分 类 号：R541.75[医药卫生—心血管疾病]