单硝酸异山梨酯对不同Apelin-13水平的老年急性心肌梗死患者心肌损伤标志物的影响  

Influence of isosorbide mononitrate on biomarkers of myocardial injury in elderly patients with acute myocardial infarction with different levels Apelin-13

作　　者：蒋茜[1] 常虹[1] 裴雪琴 梁平[1] 胡广梅[1] Jiang Qian;Chang Hong;Pei Xueqin;Liang Ping;Hu Guangmei(Department of Hypertension,Center of Cardiovascular Medicine,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;不详)

机构地区：[1]新疆医科大学第一附属医院心血管中心高血压科,乌鲁木齐830000

出　　处：《中国循证心血管医学杂志》2024年第12期1512-1515,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的分析单硝酸异山梨酯对不同孤独G蛋白偶联受体配体-13(Apelin-13)水平的老年急性心肌梗死(AMI)患者心肌损伤标志物的影响。方法选择2021年1月至2024年1月于新疆医科大学第一附属医院就诊AMI的老年患者146例为研究对象,以Apelin-13水平15.00 ng/ml为临界值,将Apelin-13>15.00 ng/ml作为高表达组,Apelin-13≤15.00 ng/ml作为低表达组,每组各73例。所有患者均予以单硝酸异山梨酯治疗,检测两组的心功能、心肌损伤标志物、血管内皮功能、血流动力学等指标,并评估治疗效果。结果治疗后,与高表达组比较,低表达组左心室舒张末期内径(LVEDD)、心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)、N末端脑钠肽前体(NT-proBNP)、血管内皮生长因子(VEGF)、血管性血友病因子(vWF)、血浆内皮素-1(ET-1)、全血比黏度低切(BVL)、全血比黏度高切(BVH)、红细胞聚集指数(EAI)、纤维蛋白原(Fib)水平均降低(P<0.05);左室最大充盈速率(LVPFR)、左室射血分数(LVEF)水平均升高(P<0.05);低表达组治疗总有效率高于高表达组(P<0.05)。结论Apelin-13≤15.00 ng/ml的AMI老年患者应用单硝酸异山梨酯治疗后,心功能、心肌损伤标志物、血管内皮功能、血流动力学情况均予以改善,疗效满意。Objective To analyze the influence of isosorbide mononitrate on biomarkers of myocardial injury in elderly patients with acute myocardial infarction(AMI)with different levels of Apelin-13.Methods AMI patients(n=146)were chosen from the First Affiliated Hospital of Xinjiang Medical University from Jan.2021 to Jan.2024.Taken 15.00 ng/ml of Apelin-13 as cut-off value,the patients with Apelin-13>15.00 ng/ml were included into high-expression group and those with Apelin-13≤15.00 ng/ml,into low-expression group(each n=73).All patients were treated with isosorbide mononitrate.The indexes of heart function,myocardial injury biomarkers,vascular endothelial function and hemodynamics were detected,and curative effect was reviewed in 2 groups.Results After treatment,the levels of left ventricular end-diastolic diameter(LVEDD),cardiac troponin I(cTnI),creatine kinase-MB isoenzyme(CK-MB),N-terminal pro-brain natriuretic peptide(NT-proBNP),vascular endothelial growth factor(VEGF),von Willebrand factor(vWF),plasma endothelin-1(ET-1),whole blood viscosity at low share rate(BVL),whole blood viscosity at high share rate(BVH),red blood cell aggregation index(RBCAI)and fibrinogen(FIB)all decreased,and left ventricular peak filling rate(LVPFR)and left ventricular ejection fraction(LVEF)increased in low-expression group compared with high-expression group(P<0.05).The total effective rate was higher in low-expression group than that high-expression group(P<0.05).Conclusion After treated with isosorbide mononitrate,the conditions of heart function,biomarkers of myocardial injury,vascular endothelial function and hemodynamics are improved and curative effect is satisfactory in elderly AMI patients with Apelin-13≤15.00 ng/ml.

关 键 词：单硝酸异山梨酯 孤独G蛋白偶联受体配体-13 急性心肌梗死 心肌损伤标志物 

分 类 号：R542.22[医药卫生—心血管疾病]