火龙灸联合少腹逐瘀膏穴位贴敷治疗盆腔炎性疾病后遗症寒凝血瘀证的临床研究  

Clinical study on the combination of Huolong Moxibustion and Shaofu Zhuyu Ointment acupoint application in the treatment of sequelae of pelvic inflammatory disease with cold coagulation and stasis syndrome

作　　者：邵娟 党颖 郑霞 同虹宇 Shao Juan;Dang Ying;Zheng Xia;Tong Hongyu(Department of Obstetrics and Gynecology,Shaanxi Provincial Hospital of Integrated Chinese and Western Medicine,Xi'an 710082,China)

机构地区：[1]陕西省中西医结合医院妇产科,西安710082

出　　处：《国际中医中药杂志》2024年第12期1577-1582,共6页International Journal of Traditional Chinese Medicine

基　　金：陕西省中医药管理局中医药科研项目(2021-GJ-LC008)。

摘　　要：目的评价火龙灸联合少腹逐瘀膏穴位贴敷治疗盆腔炎性疾病后遗症寒凝血瘀证患者的临床疗效。方法随机对照试验研究。选择2021年6月-2023年6月本院盆腔炎症性疾病患者102例作为观察对象,采用随机数字表法分为2组,每组51例。对照组予以西医常规疗法治疗,10 d为1个疗程,共治疗3个疗程;观察组予以火龙灸联合少腹逐瘀膏穴位贴敷治疗,3 d治疗1次,5次为1个疗程,共治疗3个月经周期。分别于治疗前后进行中医证候评分,采用多普勒超声诊断仪检测子宫动脉收缩期最大血流速度(PSV)、舒张末期血流速度(EDV)、搏动指数(PI)、阻力指数(RI),采用ELISA法检测血清β内啡肽(β-EP)、前列腺素F2α(PGF2α)、血清P物质(SP)水平,记录治疗期间的不良反应,评价临床疗效。结果观察组总有效率为92.16%(47/51)、对照组为76.47%(39/51),2组比较差异有统计学意义(χ^(2)=4.74,P=0.029)。治疗后,观察组腹痛拒按[(1.76±0.45)分比(2.12±0.54)分,t=3.66]、肢冷畏寒[(1.85±0.47)分比(2.21±0.60)分,t=3.37]、行经不畅[(1.93±0.56)分比()2.31±0.58分,t=3.37]、舌紫苔白[(2.04±0.55)分比(2.52±0.50)分,t=4.25]积分及总分[(7.58±1.56)分比(9.16±1.92)分,t=4.56]低于对照组(P<0.01);子宫动脉EDV[(18.86±3.65)cm/s比(14.45±3.51)cm/s,t=6.23]、PSV[(37.94±5.19)cm/s比(32.21±4.97)cm/s,t=5.70]高于对照组(P<0.01);RI[(72.62±7.56)%比(78.31±6.58)%,t=4.05]、PI[(41.94±5.90)%比(47.52±5.59)%,t=4.90]低于对照组P<0.01);β-EP[(49.86±5.87)μg/L比(55.41±5.91)μg/L,t=4.76]、PGF2α[(71.94±8.13)μg/L比(78.21±8.97)μg/L,t=3.70]、SP[(19.12±3.98)μg/L比(22.34±3.81)μg/L,t=4.17]水平低于对照组(P<0.05)。观察组治疗期间不良反应发生率为11.76%(6/51)、对照组为3.9%(2/51),2组比较差异无统计学意义(χ^(2)=0.44,P=0.505)。结论火龙灸联合少腹逐瘀膏穴位贴敷可有效改善盆腔炎性疾病后遗症寒凝血瘀证患者子宫动脉的微循环状态,降低疼痛因子水Objective To evaluate the clinical efficacy of Huolong moxibustion combined with Shaofu Zhuyu ointment acupoint application in the treatment of sequelae of pelvic inflammatory disease with cold coagulation and stasis syndrome.Methods Randomized controlled trial study was performed.102 patients with pelvic inflammatory disease in our hospital from June 2021 to June 2023 were selected as the observation subjects.They were divided into two groups according to random number table method,with 51 cases in each group.The control group was treated with conventional Western medicine therapy,with 10 days as one course of treatment,for a total of 3 courses of treatment.The observation group was treated with Huolong Moxibustion combined with Shaofu Zhuyu Ointment acupoint application,once every 3 days,with 5 sessions as a course of treatment,for a total of 3 menstrual cycles.TCM syndrome scores were performed before and after treatment;doppler ultrasound diagnostic instrument was used to detect the maximum systolic blood flow velocity(PSV),end diastolic blood flow velocity(EDV),pulsatile index(PI),and resistance index(RI)of the uterine artery;ELISA was used to detect levels ofβ-endorphin(β-EP),prostaglandin F2α(PGF2α),and serum substance P(SP).Adverse reactions during treatment were recorded,and clinical efficacy was evaluated.Results The total effective rate of the observation group was 92.16%(47/51),while that of the control group was 76.47%(39/51),the difference between the two groups was statistically significant(χ^(2)=4.74,P=0.029).After treatment,the observation group had lower abdominal pain refusal to press(1.76±0.45 vs.2.12±0.54,t=3.66),limb coldness and chills(1.85±0.47 vs.2.21±0.60,t=3.37),menstrual disorders(1.93±0.56 vs.2.31±0.58,t=3.37),tongue purple coating white score(2.04±0.55 vs.2.52±0.50,t=4.25)and total score(7.58±1.56 vs.9.16±1.92,t=4.56)than the control group(P<0.01);the EDV[(18.86±3.65)cm/s vs.(14.45±3.51)cm/s,t=6.23]and PSV[(37.94±5.19)cm/s vs.(32.21±4.97)cm/s,t=5.70]of the uterine

关 键 词：盆腔炎性疾病 寒凝血瘀 火龙灸 少腹逐瘀膏穴位贴敷 中医药疗法 

分 类 号：R246.3[医药卫生—针灸推拿学]