黄芪治疗缺血性卒中作用机制研究进展  

Research progress in the mechanism of Astragali Radix in the treatment of ischemic stroke

作　　者：金常鑫 李若冰 辜耀东 蒋希成 Jin Changxin;Li Ruobing;Gu Yaodong;Jiang Xicheng(Master Degree Student of Grade 2022,Medical College of Basic Medicine,Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China;Doctoral Degree Student of Grade 2022,Medical College of Basic Medicine,Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China;Medical College of Basic Medicine,Heilongjiang University of Traditional Chinese Medicine,Harbin 150000,China)

机构地区：[1]黑龙江中医药大学基础医学院,哈尔滨150000

出　　处：《国际中医中药杂志》2024年第12期1677-1680,F0003,共5页International Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金(82174261);黑龙江省自然科学基金(LH2021H084)。

摘　　要：黄芪的有效成分及含黄芪成药与制剂可通过抗氧化应激、抑制细胞凋亡、保护血脑屏障、减轻炎症反应、抑制铁死亡、促进神经细胞再生和新血管生成等药理作用,发挥对脑组织的保护作用。黄芪治疗缺血性卒中的基础研究中,实验指标重复率较高,应加强信号通路及增加细胞类型等上游水平的研究,且基础研究应与临床研究达成有效衔接。The active components of Astragali Radix,its patent drugs and preparations can play a protective role on brain tissue through a variety of pharmacological effects such as anti-oxidative stress,inhibition of cell apoptosis,protection of blood-brain barrier,alleviation of inflammatory response,inhibition of ferroptosis,promotion of nerve cell regeneration and new angiogenesis.In the basic research of Astragali Radix in the treatment of ischemic stroke,the repetition rate of experimental indexes is high.The research on upstream levels such as signal pathway and cell type should be strengthened,and the basic research should be effectively connected with clinical research.

关 键 词：黄芪(中药) 缺血性脑卒中 脑缺血再灌注损伤 综述 

分 类 号：R277.7[医药卫生—中医学]