neo-Dicitrinols A–C:Unprecedented PKS-NRPS hybrid citrinin dimers with ferroptosis inhibitory activity from the deep-sea-derived Penicillium citrinum W22  

作　　者：Zheng-Biao Zou Tai-Zong Wu Chun-Lan Xie Yuan Wang Yan Li Gang Zhang Rong Chao Lian-Zhong Luo Li-Sheng Li Xian-Wen Yang 

机构地区：[1]School of Pharmacy,Hainan Medical University,Haikou 571199,China [2]Key Laboratory of Marine Genetic Resources,Third Institute of Oceanography,Ministry of Natural Resources,Xiamen 361005,China [3]The School of Basic Medical Sciences,Fujian Medical University,Fuzhou 350122,China [4]Fujian Province Universities and Colleges Engineering Research Center for Marine Biopharmaceutical Resource Utilization,Xiamen Medica College,Xiamen 361023,China

出　　处：《Chinese Chemical Letters》2024年第12期466-469,共4页中国化学快报（英文版）

基　　金：financially supported by the Xiamen Southern Oceanographic Center(No.22GYY007HJ07)。

摘　　要：The chemical investigation into the EtOAc extract of the deep-sea-derived fungus Penicillium citrinum W22 yielded three unprecedented citrinin dimers,neo-Dicitrinols A–C(1–3)and a known one,penicitrinone A(4).Their structures were elucidated by extensive analysis of spectroscopic data,electronic circular dichroism(ECD)calculation,X-ray diffraction,and biogenetic consideration.neo-Dicitrinols A–C(1–3),bearing a tetramic acid unit,represent the first example of citrinin analogues as hybrid polyketide synthase-nonribosomal peptide synthase(PKS-NRPS)products.neo-Dicitrinol C(3)significantly inhibited renin-angiotensin system-selective lethal 3(RSL3)-induced ferroptosis with a half maximal effective concentration(EC50)value of 21.6μmol/L.

关 键 词：DEEP-SEA Fungus Citrinin dimers PKS-NRPS hybrid Ferroptosis 

分 类 号：TQ460.1[化学工程—制药化工]