基于成骨机制及骨结构的骨组织工程研究进展  

Research progress of bone tissue engineering based on osteogenic mechanism and bone structure development

作　　者：端嘉骅 赵建宁 DUAN Jia-hua;ZHAO Jian-ning(Department of Orthopaedics,Nanjing Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing,Jiangsu,210002,China)

机构地区：[1]南京大学医学院附属金陵医院骨科,江苏省210002

出　　处：《中国骨与关节杂志》2024年第12期1051-1056,共6页Chinese Journal of Bone and Joint

基　　金：东部战区总医院博士后基金项目(46313)。

摘　　要：骨组织具有一定的再生能力,较小的损伤可以自然愈合,但骨缺损超过临界阈值(通常为2 cm)被称为大段骨缺损,将无法自然愈合[1-2]。大段骨缺损的概念由Schmitz等[3]在1986年首次提出,其研究表明在无外界干预的条件下,骨缺损存在一个无法自愈的临界值。2015年,Mauffrey等[4]将大段骨缺损定义为缺损尺寸>2 cm或超过骨周径50%的骨缺损。创伤、退行性疾病、先天性缺陷和肿瘤切除均可导致大段骨缺损,如果要实现骨组织完全愈合和功能恢复,则需要临床干预[5]。Bone defects caused by trauma,infection,tumor,and congenital malformation are difficult to heal naturally,which usually require clinical intervention.Autologous bone transplantation is the“gold standard”in clinical treatment of bone defects,but it faces the shortcomings of limited donors.Bone tissue engineering has brought new hope for bone defect repair.In order to develop bone tissue engineering materials that meet clinical needs,it is necessary to simulate biological signals and bone structure.In this paper,the osteogenic mechanism and bone structure of bone tissue regeneration are reviewed,which will provide help and inspiration for the design of bone tissue engineering biomaterials.

关 键 词：骨生成 骨再生 组织工程 综述 

分 类 号：R318[医药卫生—生物医学工程]