Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study  

作　　者：Qiang Ma Ya-Qi Li Qing-Tang Meng Bo Yang Hai-Tao Zhang Hua Shi Chang-You Liu Tian-Chao Xiang Na Zhao Jia Rao 

机构地区：[1]Department of Nephrology,Tai’an Maternal and Child Health Hospital,Tai’an,China [2]Department of Nephrology,Children’s Hospital of Fudan University,National Children’s Medical Center,399 Wanyuan Road,Shanghai,China [3]Department of Obstetrics,Tai’an Maternal and Child Health Hospital,Tai’an,China [4]Department of Color Ultrasound,Tai’an Maternal and Child Health Hospital,Tai’an,China [5]Department of Neonatology,Tai’an Maternal and Child Health Hospital,Tai’an,China [6]Shanghai Kidney Development and Pediatric Kidney Disease Research Center,Shanghai,China [7]Shanghai Key Lab of Birth Defect,Children’s Hospital of Fudan University,Shanghai,China [8]National Key Laboratory of Kidney Diseases,Beijing,China

出　　处：《World Journal of Pediatrics》2024年第11期1168-1178,共11页世界儿科杂志（英文版）

基　　金：supported by the National Key Research and Development Program of China(2021YFC2701101,to RJ);the Program of Shanghai Academic/Technology Research(23141900700,to RJ).

摘　　要：Background Congenital anomalies of the kidneys and urinary tract(CAKUT)are the most common cause of prenatally diagnosed developmental malformation.This study aimed to assess the relationship between maternal diseases and CAKUT in offspring.Methods This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical center.Medical information on maternal noncommunicable diseases,including obesity,hypertension,diabetes mellitus,kidney disease,hyperthyroidism,hypothyroidism,psychiatric disease,epilepsy,cancer,and autoimmune disease was collected.Based on the records of ultrasound scanning during the third trimester,the diagnosis was classified as isolated urinary tract dilation(UTD)or kidney anomalies.Multivariate logistic regression was performed to establish models to predict antenatal CAKUT.Results Among the 19,656 pregnant women,perinatal ultrasound detected suspicious CAKUT in 114(5.8/1000)fetuses,comprising 89 cases with isolated UTD and 25 cases with kidney anomalies.The risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes,thyroid dysfunction,neuropsychiatric disease,anemia,ovarian and uterine disorders.A prediction model for isolated UTD was developed utilizing four confounding factors,namely gestational diabetes,gestational hypertension,maternal thyroid dysfunction,and hepatic disease.Similarly,a separate prediction model for kidney anomalies was established based on four distinct confounding factors,namely maternal thyroid dysfunction,gestational diabetes,disorders of ovarian/uterine,and kidney disease.Conclusions Isolated UTD and kidney anomalies were associated with different maternal diseases.The results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.

关 键 词：Congenital anomalies of the kidney and urinary tract(CAKUT) Kidney anomalies Predictive model Risk factors Urinary tract dilation(UTD) 

分 类 号：R69[医药卫生—泌尿科学]