以生理学特征为指导的阻塞性睡眠呼吸暂停优化治疗  

Optimal treatment of obstructive sleep apnea guided by physiological characteristics

作　　者：乌日里嘎 刘旭[1] 胡克[1] Yue Wuriliga;Liu Xu;Hu Ke(Third Department of Respiratory and Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院呼吸与危重症医学三科,武汉430060

出　　处：《中华结核和呼吸杂志》2024年第12期1181-1186,共6页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(82270101)。

摘　　要：阻塞性睡眠呼吸暂停(OSA)是一种常见的异质性疾病。尽管多数患者能获得良好治疗, 但仍有不少患者的治疗效果欠佳。生理学特征异常是OSA的重要病理生理学机制, 对临床治疗具有指导意义。本文介绍了与OSA治疗效果相关的四种生理学特征以及对这些特征的检测方法, 继而介绍基于这些特征对OSA治疗的指导意义, 为OSA患者个体化治疗提供参考。Obstructive sleep apnea(OSA)is a common and heterogeneous disorder.Most patients can be successfully treated,but some have poor treatment outcomes.This review first presented four physiological OSA characteristics,including upper airway collapsibility,loop gain,airway muscle responsiveness,and arousal threshold,which are associated with the efficacy of OSA therapy.Then,we presented how to select the most effective therapy modality for each individual based on OSA characteristics,with the purpose of providing a basis for individualized treatment of OSA.

关 键 词：阻塞性睡眠呼吸暂停 异质性疾病 个体化治疗 生理学特征 优化治疗 病理生理学机制 OSA 检测方法 

分 类 号：R766[医药卫生—耳鼻咽喉科]