急性心肌梗死患者血清Lp-PLA2、MyO、LDH在PCI术后的水平变化及与短期发生MACE的相关性分析  

Changes of serum Lp-PLA2,MyO and LDH in patients with acute myocardial infarction after PCI and their correlation with short-term MACE

作　　者：王娟[1] 梁艳波 Wang Juan;Liang Yabo(Zhengzhou First People's Hospital,Zhengzhou 450000,Henan;Zhengzhou Central Hospital450000 Zhengzhou,Henan)

机构地区：[1]郑州市第一人民医院,河南郑州450000 [2]郑州市中心医院,河南郑州450000

出　　处：《辽宁医学杂志》2024年第6期39-42,共4页Medical Journal of Liaoning

摘　　要：目的 探讨急性心肌梗死(AMI)患者经皮冠状动脉介入术(PCI)后血清脂蛋白相关磷脂酶A2(Lp-PLA2)、肌红蛋白(MyO)、乳酸脱氢酶(LDH)水平变化,分析其对主要不良心血管事件(MACE)的预测价值。方法 选取2021年1月—2023年1月于本院行PCI治疗的96例AMI患者为研究对象,依据PCI后6个月是否发生MACE分为发生组27例、未发生组69例。比较两组PCI术前、术后14d血清Lp-PLA2、MyO、LDH水平。比较两组临床资料并分析血清Lp-PLA2、MyO、LDH水平与Killip分级、Gensini积分、全球急性冠状动脉事件注册(GRACE)评分相关性。采用受试者工作特征曲线(ROC)分析术后14d血清Lp-PLA2、MyO、LDH水平对MACE发生的预测价值。结果 术后14d发生组血清Lp-PLA2、MyO、LDH水平高于未发生组(P<0.05);血清Lp-PLA2、MyO、LDH水平与Killip分级、Gensini积分、GRACE评分呈正相关(P<0.05);血清Lp-PLA2、MyO、LDH水平联合预测MACE发生的AUC大于单项指标预测(P<0.05)。结论 AMI患者PCI术后血清Lp-PLA2、MyO、LDH水平升高与MACE发生密切相关,联合检测其水平对MACE发生具有一定预测价值。Objective To investigate the changes of serum lipoprotein-associated phospholipase A2(Lp-PLA2),myo-globin(MyO)and lactate dehydrogenase(LDH)levels in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI),and to analyze their predictive value for major adverse cardiovascular events(MACE).Meth-ods A total of 96 patients with AMI who underwent PCI in our hospital from January 2021 to January 2023 were selected as the study objects.According to whether MACE occurred 6 months after PCI,they were divided into the occurrence group(27 cases)and the non-occurrence group(69 cases).Serum Lp-PLA2,MyO and LDH levels were compared between the two groups before and 14 days after PCI.The clinical data of the two groups were compared and the correlation of serum Lp-PLA2,MyO,LDH levels with Killip grade,Gensini score,and Global Register of Acute Coronary Events(GRACE)score was analyzed.The predictive value of serum Lp-PLA2,MyO and LDH levels on the occurrence of MACE 14 days after surgery was analyzed by receiver operating characteristic curve(ROC).Results The serum levels of Lp-PLA2,MyO and LDH in the group with occurrence were higher than those in the group without occurrence 14 days after operation(P<0.05).Serum Lp-PLA2,MyO and LDH levels were positively correlated with Killip grade,Gensini score and GRACE score(P<0.05).The AUC of serum Lp-PLA2,MyO and LDH combined predicted MACE was higher than that of single index(P<0.05).Conclu-sion The increase of serum Lp-PLA2,MyO and LDH levels in AMI patients after PCI is closely related to the occurrence of MACE.The combined detection of LP-PLA2,MYO and LDH levels has certain predictive value for the occurrence of MACE.

关 键 词：急性心肌梗死 经皮冠状动脉介入术 主要不良心血管事件 脂蛋白相关磷脂酶A2 肌红蛋白 乳酸脱氢酶 

分 类 号：R542.22[医药卫生—心血管疾病]