肝豆状核变性行肝移植术后早期分娩1例  

Delivery in early post-liver transplantation period in a patient with Wilson's disease:one case report

作　　者：李国耀 谢炎 孙岩岩 吕兵 孙纪三[1] Li Guoyao;Xie Yan;Sun Yanyan;Lyu Bing;Sun Jisan(Department of Organ Transplantation,First Central Municipal Hospital&Tianjin Municipal Clinical Research Center for Organ Transplantation&Key Laboratory for Organ Transplantation,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院器官移植中心,天津市器官移植临床医学研究中心,天津市器官移植重点实验室,天津300192

出　　处：《中华器官移植杂志》2024年第12期900-902,共3页Chinese Journal of Organ Transplantation

基　　金：国家自然科学基金(81870444)。

摘　　要：通过回顾1例移植术前有习惯性流产的肝豆状核变性患者,因肝功能失代偿接受原位肝移植手术并于术后9个月妊娠且成功分娩的临床资料,探讨肝移植对肝豆状核变性患者妊娠的影响,并对相关文献进行复习。该例受者术后已随访4年余,产妇及幼儿均体健。这一结果提示,肝移植手术可能可以提高肝豆状核变性受者的妊娠成功率。妊娠期间应继续进行抗排斥治疗,同时要注意避免使用哺乳动物雷帕霉素靶蛋白抑制剂、霉酚酸酯和硫唑嘌呤类药物。The relevant clinical data were reviewed for a female patient of Wilson's disease(WD)with habitual abortion.After orthotopic liver transplantation(LT)due to liver dysfunction compensation,she became pregnant and successfully delivered a healthy baby at Month 9 post-LT.This study explored the impact of LT on pregnancy in WD patients and reviewed the related literature.The recipient has been followed up for over 4 years post-LT.Both mother and child are healthy.It suggested that LT surgery can boost the pregnancy success rate of WD patients.Immunosuppressants may be maintained during pregnancy while avoiding the dosing of mTOR inhibitors,mycophenolate mofetil and azathioprine.

关 键 词：肝移植 肝豆状核变性 妊娠 流产 

分 类 号：R657.3[医药卫生—外科学] R714[医药卫生—临床医学]