胰肾联合移植后急性移植物抗宿主病1例  

Acute graft-versus-host disease after simultaneous pancreas and kidney transplantation: one case report

作　　者：胡露 郑建明[2] 粘烨琦 王振[2] 王辉[2] 冯钢[2] 赵杰[2] 宋文利[2] Hu Lu;Zheng Jianming;Nian Yeqi;Wang Zhen;Wang Hui;Feng Gang;Zhao Jie;Song Wenli(First Central College of Medicine,Tianjin Medical University,Tianjin 300041,China;Department of Pancreas Transplantation,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津医科大学一中心临床学院,天津300041 [2]天津市第一中心医院胰腺移植科,天津300192

出　　处：《中华器官移植杂志》2024年第12期907-910,共4页Chinese Journal of Organ Transplantation

摘　　要：本研究报告1例胰肾联合移植术后急性移植物抗宿主病(acute graft versus host disease,aGVHD)。受者于术后第17天陆续出现包括发热、肝功能指标异常、肠梗阻、皮疹和骨髓抑制等典型临床表现,血液中供者来源细胞游离DNA(donor-derived cell-free DNA,dd-cf DNA)占比为8.66%,诊断为aGVHD,给予大剂量糖皮质激素冲击等治疗。受者病情进展迅速,术后第24天死于多器官功能衰竭。One case of acute graft-versus-host disease(aGVHD)after simultaneous pancreas and kidney(SPK)transplantation was described.The recipient exhibited typical clinical manifestations,including fever,abnormal liver function tests,intestinal obstruction,rash and myelosuppression since Day 17 post-SPK.The proportion of donor-derived cell-free DNA(dd-cfDNA)in blood was 8.66%,confirming a diagnosis of aGVHD.Despite high-dose glucocorticoid pulse therapy,patient status rapidly deteriorated and death due to multi-organ failure occurred at Day 24 post-SPK.

关 键 词：胰肾联合移植 急性移植物抗宿主病 并发症 

分 类 号：R699.2[医药卫生—泌尿科学] R657.5[医药卫生—外科学]