降压膳食疗法(DASH)对子痫前期风险人群母儿结局的影响  

The efficacy of the dietary approaches to stop hypertension(DASH)on maternal and fetal outcome in women with risk of pre-eclampsia

作　　者：肖寒 郑秀惠 高翔 普小芸 许红霞 黄畅晓 黄溦 郭建新 Xiao Han;Zheng Xiuhui;Gao Xiang;Pu Xiaoyun;Xu Hongxia;Huang Changxiao;Huang Wei;Guo Jianxi(Department of Obstetrics and Gynecology,Army Medical Center of PLA,Army Medical University,Chongqing 400042,P.R.China)

机构地区：[1]陆军军医大学陆军特色医学中心妇产科,重庆400042

出　　处：《中国计划生育和妇产科》2024年第12期55-60,共6页Chinese Journal of Family Planning & Gynecotokology

基　　金：重庆市科卫联合医学科研项目(项目编号:2019ZDXM009)。

摘　　要：目的探讨降压膳食疗法(dietary approaches to stop hypertension,DASH)对子痫前期(pre-eclampsia,PE)风险人群母儿结局的影响。方法纳入2022年11月至2023年5月在陆军军医大学陆军特色医学中心门诊建档并有PE风险因素的175例孕妇作为研究对象,随机数字表法分为干预组(89例)和对照组(86例)。两组均行常规产检和孕期保健,干预组在此基础上按照DASH饮食原则进行指导。随访至产后42 d,比较两组孕产妇及新生儿结局。结果干预组孕晚期收缩压、孕产妇并发症总发生率低于对照组,差异有统计学意义(P<0.05)。两组分娩孕周、孕期体重增长、PE及其他妊娠期并发症发生率、血脂、胆汁酸、血清蛋白、电解质、25羟维生素D、维生素B12、同型半胱氨酸等水平、新生儿体重及Apgar评分比较,差异无统计学意义(P>0.05)。结论DASH有助于改善PE风险人群孕期血压变化,主要体现在维持收缩压稳定性,同时可降低围孕期母儿常见并发症的总体发生率,值得推广。Objective To explore the effect of dietary approaches to stop hypertension(DASH)on maternal and fetal outcomes in women with risk of preeclampsia(PE).Methods 175 pregnant women with PE risk factors who were registered in the outpatient department of Army Medical Center of PLA from November 2022 to May 2023 were included as the research subjects and randomly divided into intervention group(89 cases)and control group(86 cases)according to the random number table method.Both groups received routine prenatal examination and pregnancy health care.And the intervention group was was guided by the DASH dietary principles on this basis.Followed-up until 42 days postpartum to compare maternal and neonatal outcomes between the two groups.Results The systolic blood pressure in the third trimester and the total incidence of maternal complications in the intervention group were lower than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in gestational week,gestational weight gain,incidence of PE and other pregnancy complications,serum lipid,bile acid,serum protein,electrolyte,25-OH VitD,vitamin B12,homocysteine level,neonatal weight and Apgar scores between the two groups(P>0.05).Conclusion DASH diet can improve the change of blood pressure in wowen with risk of PE during pregnancy,which is mainly reflected in maintaining the stability of systolic blood pressure,and can reduce the overall incidence of common complications during perinatal pregnancy,which is worth promoting.

关 键 词：降压膳食疗法 妊娠期高血压疾病 子痫前期 风险因素 妊娠结局 

分 类 号：R714.244[医药卫生—妇产科学]