2型糖尿病患者血清肿瘤标志物水平变化及其与HbA1c、糖化白蛋白的相关性  

Changes of Serum Tumor Markers in Patients with Type 2 Diabetes Mellitus and their Correlation with HbA1c and Glycated Albumin

作　　者：李亦君[1] 杨琛 陈雪[1] 王君宇 郭博施 苏海鑫 李艳[1] LI Yijun;YANG Chen;CHEN Xue;WANG Junyu;GUO Boshi;SU Haicin;LI Yan(Department of Clinical Laboratory,Dongzhimen Hospital of Beijing University of Chinese Medicine,Beijing 1ol12l,China)

机构地区：[1]北京中医药大学东直门医院通州院区检验科,北京101121

出　　处：《中国实验诊断学》2024年第12期1478-1482,共5页Chinese Journal of Laboratory Diagnosis

摘　　要：目的探究2型糖尿病患者血清中9种肿瘤标志物水平的变化,并分析其与血糖控制水平(HbA1c和糖化白蛋白)的相关性。方法选择2023年1月至2023年9月北京中医药大学东直门医院通州院区就诊的131例2型糖尿病患者作为研究组;选择同期于该院就诊的68例非糖尿病的体检者作为对照组。比较两组血清中NSE、CYFRA21-1、SCC、AFP、CEA、Ferritin、CA19-9、CA125和CA15-3等9种肿瘤标志物的水平变化,使用Pearson相关性分析这些肿瘤标志物与血糖控制水平(HbA1c和糖化白蛋白)的相关性。结果2型糖尿病患者血清中的CA19-9、CA125、CEA和CYFRA21-1水平显著高于对照组,而AFP水平显著低于对照组(P<0.05)。相关性分析结果显示2型糖尿病患者HbA1c、糖化白蛋白均与血清中的CEA、CA19-9和CA125水平显著正相关(P<0.05)。结论2型糖尿病患者血清中AFP水平降低;CEA、CA19-9、CA125和CYFRA21-1等肿瘤标志物升高;且部分项目与血糖控制水平相关。Objective To explore the changes of nine tumor markers in the serum of patients with type 2 diabetes mellitus,and to analyze their correlation with blood glucose control levels(HbA1c and glycosylated albumin).Methods 131 patients with type 2 diabetes mellitus who visited the Tongzhou District of Dongzhimen Hospital of Beijing University of Chinese Medicine from January 2023 to September 2023 were selected as the study group,and 68 non-diabetes physical examiners who visited the hospital at the same time were selected as the control group.Compare the levels of 9 tumor markers,including NSE,CYFRA21-1,SCC,AFP,CEA,Ferritin,CA19-9,CA125,and CA15-3,in two groups.Use Pearson correlation analysis to examine the correlation between these tumor markers and blood glucose control levels(HbA1c and glycated albumin).Results The serum levels of CA19-9,CA125,CEA,and CYFRA21-1 in patients with type 2 diabetes mellitus were significantly higher than those in the control group,while the level of AFP was significantly lower than that in the control group(P<0.05).The results of correlation analysis showed that HbA1c and glycosylated albumin in patients with type 2 diabetes mellitus were significantly and positively correlated with the levels of CEA,CA19-9,and CA125 in serum(P<0.05).Conclusion The level of AFP in the serum of patients with type 2 diabetes mellitus was decreased;tumor markers such as CEA,CA19-9,CA125,and CYFRA21-1 were elevated and partially correlated with blood glucose control levels.

关 键 词：2型糖尿病 HBA1C 糖化白蛋白 肿瘤标志物 相关性 

分 类 号：R587.1[医药卫生—内分泌]