健脾解毒法辅助华蟾素胶囊治疗对结直肠癌患者内分泌、代谢和癌因疲乏的影响  

Effects of Spleen-Fortifying and Detoxifying Therapy Combined with Cinobufagin Capsules on Endocrine,Metabolism,and Cancer-Related Fatigue in Patients with Colorectal Cancer

作　　者：杨迪[1] 王丽芬[2] YANG Di;WANG Lifen(Department of Oncology,Changzhou Traditional Chinese Medicine Hospital,Changzhou 213000,China;Department of Oncology,Wujin Traditional Chinese Medicine Hospital,Changzhou 213000,China)

机构地区：[1]常州市中医医院肿瘤科,江苏常州213000 [2]常州市武进中医医院肿瘤科,江苏常州213000

出　　处：《中医药学报》2025年第1期88-92,共5页Acta Chinese Medicine and Pharmacology

基　　金：江苏省自然科学基金项目(BK20201491)。

摘　　要：目的:探讨健脾解毒法辅助华蟾素胶囊治疗对结直肠癌患者内分泌、代谢和癌因疲乏的影响。方法:研究纳入2021年12月—2023年12月常州市中医医院、常州市武进中医医院收治的80例结直肠癌患者,采用摸球法分组,奇数为对照组,偶数为观察组,每组40例。两组均接受化疗治疗,对照组予以华蟾素胶囊治疗,观察组在对照组基础上加用健脾解毒法治疗,比较两组治疗前后的中医证候积分、内分泌激素水平[促肾上腺皮质激素(ACTH)、皮质醇(Cor)、游离三碘甲腺原氨酸(FT3)]、能量代谢[前白蛋白(PA)、白蛋白(ALB)、转铁蛋白(TRF)]、免疫功能[CD4+、CD8+、CD4+/CD8+]、癌因疲乏[癌因性疲乏调查量表(Piper)]。结果:治疗后,观察组不寐、乏力、脘腹胀满、心烦易怒中医证候积分得分较对照组低(P<0.05);观察组ACTH水平较对照组低(P<0.05),Cor、FT3水平较对照组高(P<0.05);观察组PA、ALB、TRF水平均较对照组高(P<0.05)。观察组CD4^(+)、CD4^(+)/CD8^(+)较对照组高(P<0.05),CD8^(+)较对照组低(P<0.05)。观察组认知、感觉、情感、行为得分较对照组低(P<0.05)。观察组出现便血、排便习惯改变、腹痛、体质量下降的比例低于对照组(P<0.05);恶心、呕吐、脱发、口腔溃疡、疲劳的发生率低于对照组(P<0.05)。结论:健脾解毒法辅助华蟾素胶囊治疗能显著提高结直肠癌患者的内分泌和代谢功能,增强免疫功能,有效缓解癌因疲乏,提高治疗效果,对提高患者的生活质量具有重要意义。Objective:To investigate the effects of spleen-fortifying and detoxifying therapy combined with cinobufagin capsules on endocrine function,metabolism,and cancer-related fatigue in patients with colorectal cancer.Methods:Eighty patients with colorectal cancer admitted to Changzhou Traditional Chinese Medicine Hospital and Wujin Traditional Chinese Medicine Hospital from December 2021 to December 2023 were included in this study.The patients were randomly divided into two groups of 40,with odd numbers assigned to the control group and even numbers to the observation group.Both groups received chemotherapy,with the control group given cinobufagin capsules and the observation group receiving additional spleen-fortifying and detoxifying therapy.Outcomes included Traditional Chinese Medicine(TCM)syndrome scores,endocrine hormone levels[adrenocorticotropic hormone(ACTH),cortisol(Cor),and free triiodothyronine(FT3)],energy metabolism markers[prealbumin(PA),albumin(ALB),and transferrin(TRF)],immune function markers[CD4^(+),CD8^(+),and CD4^(+)/CD8^(+)ratio],and cancer-related fatigue levels assessed by the Piper Fatigue Scale.Results:Post-treatment,the observation group showed lower scores in TCM syndrome indicators such as insomnia,fatigue,abdominal distension,and irritability compared to the control group(P<0.05).ACTH levels were lower(P<0.05),while Cor and FT3 levels were higher in the observation group(P<0.05).Additionally,PA,ALB,and TRF levels were significantly higher in the observation group(P<0.05).The observation group exhibited higher CD4^(+)and CD4^(+)/CD8^(+)ratios and lower CD8^(+)levels(P<0.05).Scores for cognitive,sensory,emotional,and behavioral fatigue were also lower in the observation group(P<0.05).Moreover,the observation group had lower incidences of symptoms such as bloody stool,changes in bowel habits,abdominal pain,weight loss,nausea,vomiting,hair loss,oral ulcers,and fatigue(P<0.05).Conclusion:Spleen-fortifying and detoxifying therapy combined with cinobufagin capsules significantly improves endocr

关 键 词：健脾解毒法 华蟾素胶囊 结直肠癌 内分泌 代谢紊乱 癌因疲乏 

分 类 号：R273.535[医药卫生—中西医结合]