透明质酸联合胶原蛋白注射填充改善鼻唇沟的回顾性分析  

Retrospective analysis of the effect of sodium hyaluronate combined with collagen injection on improving nasolabial groove

作　　者：张鑫鑫 陈鑫尧 李烨 张雨晨 李东岳 王晨 杜恬静 杨秀明 郝立君[2] 孙喜山 ZHANG Xinxin;CHEN Xinyao;LI Ye;ZHANG Yuchen;LI Dongyue;WANG Chen;DU Tianjing;YANG Xiuming;HAO Lijun;SUN Xishan(Department of Burn and Plastic Surgery,Third Affiliated Hospital of Naval Military Medical University,Shanghai 201805,China)

机构地区：[1]海军军医大学第三附属医院烧伤整形科,上海201805 [2]哈尔滨医科大学附属第一医院整形美容中心,黑龙江哈尔滨150001 [3]南方医科大学南方医院整形外科,广东广州510515

出　　处：《中国美容整形外科杂志》2024年第12期741-744,I0005,共5页Chinese Journal of Aesthetic and Plastic Surgery

摘　　要：目的 探讨透明质酸联合胶原蛋白注射填充改善鼻唇沟的效果。方法 回顾性分析自2022年10月至2023年10月,海军军医大学第三附属医院烧伤整形科收治35例鼻唇沟皱纹患者,采用透明质酸填充鼻基底联合胶原蛋白填充鼻唇沟皱纹,术后1、3、6、12个月进行随访并拍照记录。统计皱纹程度评定量表(wrinkle severity rating scale,WSRS)评分、GAIS评分、测量面部凸度、不良事件发生率、患者满意度。结果 35例患者注射后1、3、6、12个月WSRS评分分别为(1.23±0.42)分、(1.51±0.57)分、(1.71±0.46)分、(2.03±0.67)分;注射后1、3、6、12个月GAIS评分分别为(4.43±0.55)分、(3.77±0.54)分、(3.14±0.42)分、(2.26±0.44)分;注射后1、3、6、12个月面部凸度分别为(172.80°±1.55°)、(173.91°±1.48°)、(174.89°±1.53°)、(175.71°±1.76°),与注射前(176.63°±1.80°)比较,P值均<0.05。注射后水肿4例(11.4%)、硬结1例(2.9%)。患者总满意率为85.7%(30/35)。结论 透明质酸胶原联合蛋白注射填充改善鼻唇沟安全、舒适、有效且持久,具有较高的美学价值,是可供选择的改善鼻唇沟皱纹较好的方法。Objective To explore the effect of sodium hyaluronate gel combined with collagen injection on improving nasolabial groove.Methods From October 2022 to October 2023,35 cases of nasolabial fold wrinkles were treated in the Department of Burn and Plastic Surgery of the Third Affiliated Hospital of Naval Military Medical University.Fill the nasal base with hyaluronic acid combined with collagen to fill nasolabial fold wrinkles,and were followed up and photographed 1,3,6 and 12 months after operation.Statistical WSRS score,GAIS score,measurement of facial convexity,incidence of adverse events,patient satisfaction.Results The WSRS scores of 35 patients were(1.23±0.42),(1.51±0.57),(1.71±0.46) and(2.03±0.67) respectively at 1,3,6 and 12 months after injection.GAIS scores were(4.43 ±0.55),(3.77± 0.54),(3.14± 0.42) and(2.26±0.44) respectively at 1,3,6 and 12 months after injection.The facial convexity at 1,3,6 and 12 months after injection was(172.80°±1.55°),(173.91°±1.48°),(174.89°±1.53°) and(175.71°±1.76°) respectively,compared with that before injection(176.63°± 1.80°).There were 4 cases of edema(11.4%) and 1 case of induration(2.9%) after injection.The total satisfaction rate of patients was 85.7%(30/35).Conclusion Sodium hyaluronate gel combined with collagen injection is a safe,comfortable,effective and lasting method to improve nasolabial groove,which has high aesthetic value and is a better way to improve nasolabial fold wrinkles.

关 键 词：鼻唇沟 鼻基底 透明质酸钠凝胶 胶原蛋白 面部凸度 

分 类 号：R62[医药卫生—整形外科]