海洋中药珍珠母的研究进展  

Research Progress on Chinese Marine Medicine Margaritifera Concha

作　　者：胡玉莹 杨贵雅 陈安珍 卢京光 刘越[1] 马双成 HU Yu-ying;YANG Gui-ya;CHEN An-zhen;LU Jing-guang;LIU Yue;MA Shuang-cheng(Beijing University of Chinese Medicine,Beijing 102488,China;Qingdao Institute for Food and Drug Control,Qingdao 266071,China;Key Laboratory for Quality Research and Evaluation of Marine Traditional Chinese Medicine,National Medical Products Administration,Qingdao 260071,China;Chinese Pharmacopoeia Commission,Beijing 100061,China)

机构地区：[1]北京中医药大学,北京102488 [2]青岛市食品药品检验研究院,山东青岛266071 [3]国家药品监督管理局海洋中药质量研究与评价重点实验室,山东青岛260071 [4]国家药典委员会,北京100061

出　　处：《中国现代中药》2024年第12期2189-2196,共8页Modern Chinese Medicine

基　　金：国家药品监督管理局海洋中药质量研究与评价重点实验室开放基金课题(HYZY-KF-2022014);国家中医药管理局高水平中医药重点学科建设项目(中药化学)。

摘　　要：珍珠母作为一种常用海洋中药,主要由碳酸钙、少量的蛋白质、氨基酸或多肽类成分组成,具有促进成骨、抗惊厥和镇静催眠等药理作用,在临床上广泛用于治疗失眠、神经衰弱等疾病。珍珠母常通过明煅法进行炮制,现有质量标准多以碳酸钙的含量为指标对其进行质量控制。对珍珠母的本草记载、炮制历史、微观结构、临床应用及质量控制等方面进行梳理与总结,以期为珍珠母的开发利用和质量控制研究提供参考。Margaritifera Concha,a prominent representative of Chinese marine medicine,is commonly processed through calcination.It is primarily composed of calcium carbonate,with small amounts of proteins,amino acids,or peptides.Margaritifera Concha exhibits pharmacological effects such as osteogenic activity,anticonvulsant effects,and sedative and hypnotic properties,making it widely used in the clinical treatment of insomnia,neurasthenia,and other mental disorders.Current quality standards predominantly focus on the calcium carbonate content for quality control.This review systematically summarized the traditional records,processing history,microstructure,clinical applications,and quality control of Margaritifera Concha,aiming to provide a reference for its development,utilization,and quality assurance.

关 键 词：珍珠母 微观结构 炮制 质量控制 辨状论质 

分 类 号：R282[医药卫生—中药学]