Prefrontal cortical circuits in social behaviorss:an overview  

作　　者：Wei CAO Huiyi LI Jianhong LUO 

机构地区：[1]Institute of Brain Science and Department of Physiology,School of Basic Medical Sciences,Hangzhou Normal University,Hangzhou,311121,China [2]Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital,School of Brain Science and Brain Medicine,Zhejiang University School of Medicine,Hangzhou,310013,China [3]Zhejiang Key Laboratory of Medical Epigenetics,School of Basic Medical Sciences,Hangzhou Normal University,Hangzhou,311121,China [4]Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare,Hangzhou Normal University,Hangzhou,311121,China [5]Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province,School of Medicine,Hangzhou City University,Hangzhou,310015,China [6]NHC and CAMS Key Laboratory of Medical Neurobiology,Zhejiang University,Hangzhou,310058,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第11期941-955,共15页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the National Natural Science Foundation of China(Nos.81801355,U22A20306,and 3192010300);the Autism Research Special Fund of Zhejiang Foundation for Disabled Persons(Nos.2022001 and 2023002);the Research and Development Program of Guangdong Province(No.2019B030335001);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2023-PT310-01)。

摘　　要：Social behaviors are fundamental and intricate functions in both humans and animals,governed by the interplay of social cognition and emotions.A noteworthy feature of several neuropsychiatric disorders,including autism spectrum disorder(ASD)and schizophrenia(SCZ),is a pronounced deficit in social functioning.Despite a burgeoning body of research on social behaviors,the precise neural circuit mechanisms underpinning these phenomena remain to be elucidated.In this paper,we review the pivotal role of the prefrontal cortex(PFC)in modulating social behaviors,as well as its functional alteration in social disorders in ASD or SCZ.We posit that PFC dysfunction may represent a critical hub in the pathogenesis of psychiatric disorders characterized by shared social deficits.Furthermore,we delve into the intricate connectivity of the medial PFC(mPFC)with other cortical areas and subcortical brain regions in rodents,which exerts a profound influence on social behaviors.Notably,a substantial body of evidence underscores the role of N-methyl-D-aspartate receptors(NMDARs)and the proper functioning of parvalbumin-positive interneurons within the mPFC for social regulation.Our overarching goal is to furnish a comprehensive understanding of these intricate circuits and thereby contribute to the enhancement of both research endeavors and clinical practices concerning social behavior deficits.

关 键 词：Prefrontal cortex(PFC) Social behavior Autism spectrum disorder(ASD) Schizophrenia(SCZ) Parvalbumin-positive interneuron N-Methyl-D-aspartate receptor(NMDAR) 

分 类 号：R338[医药卫生—人体生理学]