小窝蛋白1泛素化在不同疾病中的角色与意义  

The Role and Significance of Caveolin-1 Ubiquitination in Different Diseases

作　　者：胡凤丽 王鹏飞[1] 谷国强[1] HU Feng-Li;WANG Peng-Fei;GU Guo-Qiang(Department of Cardiology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院心内科,石家庄050000

出　　处：《中国生物化学与分子生物学报》2024年第12期1683-1690,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：河北省自然科学基金资助项目(No.H2023206463);国家自然科学基金青年科学基金项目(No.82100301);2022年度河北省医学科学研究课题计划(No.20220989)资助。

摘　　要：小窝蛋白1(caveolin-1,Cav-1)是小窝的主要成分,可参与细胞膜内吞、脂质运输及信号转导等生理过程。近年来,大量研究发现,小窝蛋白1泛素化修饰既能影响自身水平,又能通过改变蛋白质结构造成相互作用分子的构象变化,进而在不同疾病中扮演不同的角色。Cav-1含12个赖氨酸残基,其中N端结构域6个赖氨酸残基(5/26/30/39/47/57)对于Cav-1的泛素化修饰必不可少。在不同疾病状态下,Cav-1的泛素化类型及位点各异,而且泛素化修饰后可通过泛素-蛋白酶体系统及溶酶体途径降解。本文通过综述Cav-1泛素化在呼吸、消化、神经、内分泌、乳腺生殖等系统疾病中的相关研究,发现Cav-1泛素化主要涉及肿瘤、炎症和代谢性疾病等病理过程。通过综述Cav-1泛素化修饰在不同疾病模型及细胞中扮演的角色,希望能加深理解Cav-1泛素化的生理和病理生理学意义,为未来可能相关干预提供方向。Caveolin-1(Cav-1)is the main component of caveolin,which can participate in physiological processes such as endocytosis,lipid transport and signal transduction.In recent years,more and more studies have found that the ubiquitination modification of Cav-1 can not only affect the level of Cav-1 itself,but also cause conformational changes of interacting molecules by changing the protein structure,and then play various roles in different diseases.Cav-1 contains 12 lysine residues,of which 6 lysine residues in the N-terminal domain(5/26/30/39/47/57)are essential for the ubiquitination of Cav-1.The types and sites of ubiquitination of Cav-1 are different in diseases,and ubiquitination can be degraded by the ubiquitin-proteasome system and lysosomal pathway.In this paper,we reviewed the relevant studies of Cav-1 ubiquitination in respiratory,digestive,neurological,endocrine,mammary reproduction and other systemic diseases,and found that Cav-1 ubiquitination mainly involves tumor,inflammation,metabolic diseases and other disease processes.By reviewing the role of Cav-1 ubiquitination in different disease models and cells,it is hoped to deepen the understanding of the physiological and pathophysiological significance of Cav-1 ubiquitination,and provide directions for possible future interventions.

关 键 词：小窝蛋白1 泛素化修饰 小窝 

分 类 号：Q241[生物学—细胞生物学]