民族药滇黄芩研究现状与思考  

Current Status and Insights of Ethnic Medicine Scutellaria amoena C.H.Wright

作　　者：宋伟 严倩茹 邬伟魁 Song Wei;Yan Qianru;Wu Weikui(Department of Pharmacy,Renmin Hospital of Wuhan University,Wuhan 430060,China;Meizhou Institute for Food and Drug Control,Meizhou 514071,China)

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]梅州市食品药品监督检验所,梅州514071

出　　处：《中国药事》2024年第12期1438-1446,共9页Chinese Pharmaceutical Affairs

基　　金：吴阶平基金会临床科研专项基金(编号320.6750.2020-04-27)。

摘　　要：目的:为民族药物重要资源滇黄芩合理开发与综合利用提供理论依据,同时提升黄芩属药材的质量可控性及临床使用安全性。方法:通过梳理滇黄芩的化学成分、药效作用和潜在的生物活性,分析其在传统医学中的应用现状和存在的问题,并提出相应的对策。结果:滇黄芩(Scutellaria amoena C.H.Wright)的干燥根,其主要化学成分黄酮物质与黄芩基本一致,且黄芩苷含量高于黄芩。此外,滇黄芩还展现出抗衰老、抗肿瘤、抗动脉粥样硬化、调血脂、降血糖、提高免疫力、改善记忆功能等潜在的生物活性。结论:滇黄芩因其丰富的化学成分和广泛的生物活性,具有较大的开发潜力。本研究提出的对策将有助于推动滇黄芩的进一步研究和应用,促进滇黄芪的临床应用和有效开发。Objective:To provide a theoretical foundation for the rational development and comprehensive utilization of Scutellaria amoena C.H.Wright which is a valuable ethnic medicinal resource,and to enhance the quality control and clinical safety of Scutellaria species.Methods:This study reviewed the chemical constituents,pharmacological activities,and potential biological effects of Scutellaria amoena C.H.Wright,evaluated its current applications in traditional medicine,identified existing issues,and proposed corresponding strategies.Results:The dried roots of Scutellaria amoena C.H.Wright primarily contain flavonoids,which are largely consistent with those in Scutellaria baicalensis,with higher levels of baicalin.Furthermore,Scutellaria amoena C.H.Wright demonstrates a range of potential biological activities,including anti-aging,anti-tumor,antiatherosclerotic,lipid-lowering,blood glucose-lowering,immune-enhancing,and cognitive-improving effects.Conclusion:Due to its rich chemical profile and broad spectrum of biological activities,Scutellaria amoena C.H.Wright has substantial potential for further development.The strategies proposed in this study will support the advancement of research and clinical application of Scutellaria amoena C.H.Wright,thereby facilitating its effective development and clinical use.

关 键 词：民族药 滇黄芩 化学成分 黄芩苷 药理作用 

分 类 号：R932[医药卫生—生药学]