估算的脉搏波传导速度的变化对心脑血管事件的影响  

Effect of estimated pulse wave velocity changes on cardiovascular and cerebrovascular events

作　　者：汪国栋[1] 王锦梅[2] 季春鹏[3] 刘妍[3] 王娜[4] 黄喆[3] WANG Guodong;WANG Jinmei;JI Chunpeng;LIU Yan;WANG Na;HUANG Zhe(Health Care Center,Tangshan,Hebei 063000,China;General Internal Medicine,Rehabilitation Hospital,Tangshan,Hebei 063000,China;Department of Cardiology,Kailuan General Hospital,Tangshan,Hebei 063000,China;Department of Cardiology,the Second Hospital of Qinhuangdao,Qinhuangdao,Hebei 066600,China)

机构地区：[1]开滦总医院员工健康保障中心,河北省唐山市063000 [2]开滦总医院康复医院普通内科,河北省唐山市063000 [3]开滦总医院心内科,河北省唐山市063000 [4]秦皇岛市第二医院心内科,河北省秦皇岛市066600

出　　处：《中国动脉硬化杂志》2024年第12期1067-1073,共7页Chinese Journal of Arteriosclerosis

基　　金：河北省卫健委青年科技课题(20210746)。

摘　　要：[目的]研究估算的脉搏波传导速度(ePWV)的变化对心脑血管事件的影响。[方法]以参加开滦集团2006—2007年度健康体检并且参加了2010—2011年度健康体检的61714例员工为研究对象,按观察期基线及观察期末的ePWV值将观察对象分为四组:持续正常组、正常-增高组、增高-正常组及持续增高组,采用Cox回归模型分析不同的ePWV变化情况对心脑血管事件的影响。[结果]平均随访时间为(8.52±1.59)年,随访结束共发生心脑血管事件3715例(6.02%),持续正常组、正常-增高组、增高-正常组、持续增高组发病密度分别为3.81、10.80、13.54、15.85/千人年。Cox回归模型分析显示,校正各种混杂因素后,与持续正常组相比,正常-增高组、增高-正常组、持续增高组发生心脑血管事件的风险显著增加,HR(95%CI)分别为2.68(2.44~2.95)、3.14(2.67~3.69)、4.03(3.71~4.38)。[结论]维持ePWV持续正常能有效减少心脑血管事件。Aim To explore the effect of estimated pulse wave velocity(ePWV)changes on cardiovascular and cerebrovascular events.Methods A total of 61714 employees who participated in the 2006—2007 physical examination and 2010—2011 physical examination of Kailuan Group were selected as the research subjects.The subjects were divided into four groups according to the ePWV values at baseline and at the end of the observation period:sustained normal group,normal-high group,high-normal group and sustained high group,Cox regression model was used to analyze the effect of different changes of ePWV on cardiovascular and cerebrovascular events.Results A total of 3715(6.02%)cases of cardiovascular and cerebrovascular events occurred after a mean follow-up of(8.52±1.59)years.The incidence density of cardiovascular events was 3.81,10.80,13.54 and 15.85 per 1000 person-year respectively in the sustained normal group,the normal-high group,the high-normal group and the sustained high group.After adjusting for confounders,the risk of cardiovascular and cerebrovascular events was significantly increased in the normal-high group,the high-normal group and the sustained high group compared with the sustained normal group,the HR(95%CI)were 2.68(2.44~2.95),3.14(2.67~3.69)and 4.03(3.71~4.38),respectively.Conclusion Maintaining normal ePWV can effectively reduce cardiovascular and cerebrovascular events.

关 键 词：估算的脉搏波传导速度 心脑血管事件 COX回归模型 

分 类 号：R5[医药卫生—内科学]