铜死亡与MIRI和心力衰竭的关系  

Cuproptosis in relation to MIRI and heart failure

作　　者：刘肖肖 李宏玉[1] 赵耀伟 马西元 董春杨 唐强[1] LIU Xiaoxiao;LI Hongyu;ZHAO Yaowei;MA Xiyuan;DONG Chunyang;TANG Qiang(Heilongjiang University of Chinese Medicine,Harbin,Heilongjiang 150006,China)

机构地区：[1]黑龙江中医药大学,黑龙江省哈尔滨市150006

出　　处：《中国动脉硬化杂志》2024年第12期1082-1088,共7页Chinese Journal of Arteriosclerosis

基　　金：黑龙江省自然科学基金重点项目(ZD2019H007)。

摘　　要：心肌梗死后及时恢复血液供应对于挽救梗死心肌至关重要。目前为止,最有效的方法是通过冠状动脉介入治疗恢复心肌氧合和冠状动脉血流,然而再灌注也有可能因分子氧的重新引入而引发更大的心脏损伤,需要新的治疗方法来保护心脏免受心肌缺血再灌注损伤(MIRI)的影响,以改善急性心肌梗死和心力衰竭(HF)患者的临床预后。深入了解MIRI的机制和寻找新的治疗手段可以为减轻心肌损伤和提高患者生存率提供关键证据。目前发现铜作为人体内一种微量元素,对MIRI具有显著的保护作用。铜可以减少心肌细胞的凋亡,即控制细胞的自我毁灭过程,从而降低心肌损伤的程度。然而,铜离子异常代谢及铜死亡与MIRI及HF之间的潜在关系仍未得到探索,在本综述中,我们重点关注MIRI的潜在治疗策略,了解铜在人体的代谢途径,为心血管疾病(CVD)的治疗提供更多的选择和希望。Timely restoration of blood supply after myocardial infarction is crucial for saving the infarcted myocardium.So far,the most effective method is to restore myocardial oxygenation and coronary blood flow through coronary interventional therapy.However,reperfusion may also lead to greater heart damage due to the reintroduction of molecular oxygen.New treatments are needed to protect the heart from myocardial ischemia-reperfusion injury(MIRI)to improve clinical outcomes in patients with acute myocardial infarction and heart failure(HF).A deeper understanding of the mechanisms of MIRI and the search for new treatments could provide key evidence to mitigate myocardial damage and improve patient survival.At present,it has been found that copper,as a trace element in human body,can have a significant protective effect on MIRI.Copper can reduce apoptosis in cardiomyocytes,that is,control the self-destruction process of cell,so as to reduce the degree of myocardial injury.However,the potential relationship between abnormal copper ion metabolism as well as cuproptosis and MIRI as well as HF has not been explored.In this review,we focus on potential therapeutic strategies for MIRI and understand the metabolic pathways of copper in the human body,so as to provide more options and hope for the treatment of cardiovascular diseases.

关 键 词：铜 心脏保护 铜死亡 心肌缺血再灌注损伤 心力衰竭 

分 类 号：R5[医药卫生—内科学]